ChemicalBook >> CAS DataBase List >>LY3039478
LY3039478
- CAS No.
- 1421438-81-4
- Chemical Name:
- LY3039478
- Synonyms
- LY3039478;Crenigacestat;LY3039478(Crenigacestat);CRENIGACESTAT (LY3039478);LY3039478; LY 3039478; LY-3039478; CRENIGACESTAT;4-trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6;Inhibitor,γ-secretase,Crenigacestat,liver,LY 3039478,Notch,Gamma secretase,inhibit,LY-3039478,CCRCC;4,4,4-Trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide;N-[(1S)-2-[[(7S)-6,7-Dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluorobutanamide;Butanamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluoro-
- CBNumber:
- CB52677403
- Molecular Formula:
- C22H23F3N4O4
- Molecular Weight:
- 464.44
- MDL Number:
- MFCD26142650
- MOL File:
- 1421438-81-4.mol
- MSDS File:
- SDS
Last updated:2023-05-21 10:59:17
| Boiling point | 818.7±65.0 °C(Predicted) |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥23.2 mg/mL in DMSO; insoluble in H2O; ≥89.4 mg/mL in EtOH with ultrasonic |
| form | solid |
| pka | 12.75±0.20(Predicted) |
| FDA UNII | 923X28214S |
| NCI Drug Dictionary | crenigacestat |
LY3039478 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27919 | Crenigacestat | 1421438-81-4 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 27919 | Crenigacestat | 1421438-81-4 | 10mg | $384 | 2024-03-01 | Buy |
| Cayman Chemical | 27919 | Crenigacestat | 1421438-81-4 | 5mg | $202 | 2024-03-01 | Buy |
| TRC | L468970 | LY3039478 | 1421438-81-4 | 1mg | $160 | 2021-12-16 | Buy |
| ChemScene | CS-5807 | Crenigacestat 98.62% | 1421438-81-4 | 5mg | $168 | 2021-12-16 | Buy |
LY3039478 Chemical Properties,Uses,Production
Uses
LY 3039478 is used in the preparation of medicaments for combination antitumor therapy with Notch and PD-1 or PD-Li inhibitors.
Biological Activity
ly3039478 is a novel and potent notch inhibitor with ic50 of 0.41 nm.the novel and unique notch inhibitor, ly3039478, has progressed into clinical development by lilly co. ltd. ly3039478 displays the best overall profile and is unique within the sar investigated. ly3039478 displays interesting atropisomer phenomena. the average ly3039478 major/minor rotational isomer ratio ranged between 14 and 28 in plasma. the crystalline monohydrate form of ly3039478 consists of a single rotational isomer and is chemically and physically stable for at least 14 days under accelerated stability test conditions.
References
warren j. porter. discovery of a novel notch inhibitor. the 8th sci-rsc symposium on proteinase inhibitor design april 15-16, 2013, basel, switzerland.
LY3039478 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 68)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18223 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
LY3039478
4,4,4-Trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide
N-[(1S)-2-[[(7S)-6,7-Dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluorobutanamide
LY3039478(Crenigacestat)
CRENIGACESTAT (LY3039478)
Butanamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluoro-
Crenigacestat
LY3039478; LY 3039478; LY-3039478; CRENIGACESTAT
4-trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6
Inhibitor,γ-secretase,Crenigacestat,liver,LY 3039478,Notch,Gamma secretase,inhibit,LY-3039478,CCRCC
1421438-81-4
C22H23F3N4O4
APIS