GardiquiMod
- CAS No.
- 1020412-43-4
- Chemical Name:
- GardiquiMod
- Synonyms
- GardiquiMod;Gardiquimod DiTFA salt;Gardiquimod >=98% (HPLC);1-(4-Amino-2-ethylaminomethylimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol;4-Amino-2-[(ethylamino)methyl]-?,?-dimethyl-1H-Imidazo[4,5-c]quinoline-1-ethanol;1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-;1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol;4-Amino-2-[(ethylamino)methyl]-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol;2-amino-9-[(2R,3S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-enyl-3H-purine-6,8-dione;HIV-1,Gardiquimod,HepG2,Toll-like Receptor (TLR),Inhibitor,PBMCs,inhibit,HIV,cells,peripheral,macrophages,blood,liver,carcinoma,Human immunodeficiency virus,mononuclear
- CBNumber:
- CB52677812
- Molecular Formula:
- C17H23N5O
- Molecular Weight:
- 313.39742
- MDL Number:
- MFCD11041176
- MOL File:
- 1020412-43-4.mol
- MSDS File:
- SDS
| Boiling point | 562.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| pka | 14.70±0.29(Predicted) |
| color | white to beige |
| FDA UNII | Y3W4QVW5BY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
GardiquiMod price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0877 | Gardiquimod ≥98% (HPLC) | 1020412-43-4 | 5mg | $73.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0877 | Gardiquimod ≥98% (HPLC) | 1020412-43-4 | 25mg | $286.8 | 2024-03-01 | Buy |
| Cayman Chemical | 18877 | Gardiquimod ≥95% | 1020412-43-4 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 18877 | Gardiquimod ≥95% | 1020412-43-4 | 10mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 18877 | Gardiquimod ≥95% | 1020412-43-4 | 25mg | $168 | 2024-03-01 | Buy |
GardiquiMod Chemical Properties,Uses,Production
Biological Activity
gardiquimod is an agonist of human toll-like receptor 7 (tlr7) [1][2].toll-like receptors (tlrs) are a family of highly conserved pattern recognition receptors involved in innate immune responses to pathogen infection. tlr7 is highly expressed by plasmacytoid dendritic cells, and is also found on other leukocyte subpopulations. tlr7 and tlr8 recognize single-stranded rna from viruses [4].gardiquimod is an agonist of human toll-like receptor 7 (tlr7), but not human tlr8, although it activates both porcine tlr7 and tlr8. in transfected 293t cells, gardiquimod preferentially activated porcine tlr8 (ptlr8) [1]. gardiquimod is a member of imidazoquinoline family. when codelivered intranasally with plant-derived norwalk virus virus-like particles (nv vlps), gardiquimod (gard) induced nv vlp-specific serum igg and igg isotype responses and mucosal iga responses in the gastrointestinal, respiratory, and reproductive tracts [3]. in macrophages and activated peripheral blood mononuclear cells (pbmcs) infected with x4, r5 or dual-tropic (r5/x4) strains of hiv-1, gardiquimod inhibited hiv-1 reverse transcriptase and significantly reduced infection. gardiquimod also induced interferon-alpha (ifn-a) transcription and sustained ifn-a protein secretion [4]. in bxpc-3 cells, gardiquimod inhibited cell proliferation and migration, and induced apoptosis [5].in c57bl/6 mice, gardiquimod enhanced the ability of treg cell to suppress the proliferation of tresp cells. the cd4+cd25+treg cells from mice that had received gardiquimod exhibited an increased inhibitory effect on anti-cd3/anti-cd28 mab-coated bead-stimulated tresp cells [2].
Biochem/physiol Actions
Gardiquimod is a potent and specific agonist for human or mouse Toll-like receptor 7 (TLR7). Also, at high concentration gardiquimod activates TLR8. Similarly to imiquimod, gardiquimod could mimic the effects of viral nucleic acids on the immune system.
storage
+4°C
References
[1]. zhu j, lai k, brownile r, et al. porcine tlr8 and tlr7 are both activated by a selective tlr7 ligand, imiquimod. mol immunol. 2008 jun;45(11):3238-43.
[2]. forward na1, furlong sj, yang y, et al. signaling through tlr7 enhances the immunosuppressive activity of murine cd4+cd25+ t regulatory cells. j leukoc biol. 2010 jan;87(1):117-25.
[3]. velasquez ls, hjelm be, arntzen cj, et al. an intranasally delivered toll-like receptor 7 agonist elicits robust systemic and mucosal responses to norwalk virus-like particles. clin vaccine immunol. 2010 dec;17(12):1850-8.
[4]. buitendijk m, eszterhas sk, howell al. gardiquimod: a toll-like receptor-7 agonist that inhibits hiv type 1 infection of human macrophages and activated t cells. aids res hum retroviruses. 2013 jun;29(6):907-18.
[5]. zou bb, wang f, li l, et al. activation of toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cells. mol med rep. 2015 oct;12(4):6079-85.
GardiquiMod Preparation Products And Raw materials
Raw materials
Preparation Products
GardiquiMod Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 18521735133 18521732826; | market@aladdin-e.com | China | 25014 | 65 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |