CW069
- CAS No.
- 1594094-64-0
- Chemical Name:
- CW069
- Synonyms
- CW069;CS-1425;CW069; CW 069;CW069 USP/EP/BP;CW-069,Inhibitor,Kinesin,inhibit,CW 069;(S)-2-(2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO)-5-IODOBENZOIC ACID;2-[(2S)-2-(Benzylamino)-3-phenylpropanamido]-5-iodobenzoic acid;5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid;Benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-
- CBNumber:
- CB52681121
- Molecular Formula:
- C23H21IN2O3
- Molecular Weight:
- 500.33
- MDL Number:
- MFCD28009372
- MOL File:
- 1594094-64-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
CW069 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22936 | CW069 ≥95% | 1594094-64-0 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 22936 | CW069 ≥95% | 1594094-64-0 | 5mg | $220 | 2024-03-01 | Buy |
| Cayman Chemical | 22936 | CW069 ≥95% | 1594094-64-0 | 10mg | $356 | 2024-03-01 | Buy |
| TRC | C857000 | CW069 | 1594094-64-0 | 25mg | $1075 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181226 | CW069 >98% | 1594094-64-0 | 250mg | $1208.7 | 2021-12-16 | Buy |
CW069 Chemical Properties,Uses,Production
Description
CW069 is an allosteric inhibitor of KIFC/HSET (IC50 = 75 μM), a microtubule motor protein involved in bipolar spindle assembly and centrosome clustering. It increases the number of multipolar spindles in N1E-115 mouse neuroblastoma cells with supernumerary centrosomes when used at concentrations of 100 and 200 μM, without affecting the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells. CW069 inhibits proliferation of N1E-115, but not NHDF, cells (IC50s = 86 and 181 μM, respectively).
Uses
CW 069 is an allosteric inhibitor of the microtubule motor protein HSET which induces multipolar mitoses only in cells containg supernumerary centrosomes.
References
[1]. watts ca, richards fm, bender a, et al. design, synthesis, and biological evaluation of an allosteric inhibitor of hset that targets cancer cells with supernumerary centrosomes. chem biol, 2013, 20(11): 1399-1410.
CW069 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27945 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |