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Cerdulatinib HCl salt

Cerdulatinib HCl salt Structure
Cerdulatinib HCl salt structure
CAS No.
1369761-01-2
Chemical Name:
Cerdulatinib HCl salt
Synonyms
Cerdulatinib HCl;PRT2070 hydrochloride;Cerdulatinib HCl salt;PRT062070 hydrochloride;Cerdulatinib hydrochloride;Cerdulatinib HCl (PRT-2070;Cerdulatinib HCl salt USP/EP/BP;Cerdulatinib (PRT062070, PRT2070);4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride;4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1)
CBNumber:
CB52728651
Molecular Formula:
C20H28ClN7O3S
Molecular Weight:
481.99942
MDL Number:
MFCD28348366
MOL File:
1369761-01-2.mol
Last updated:2023-09-04 15:50:00
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Cerdulatinib HCl salt Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO:20.0(Max Conc. mg/mL);41.49(Max Conc. mM)
FDA UNII L1KRM66Y4X

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Cerdulatinib HCl salt price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0010193 Cerdulatinib(hydrochloride) 99.54% 1369761-01-2 5mg $108 2021-12-16 Buy
ChemScene CS-0010193 Cerdulatinib(hydrochloride) 99.54% 1369761-01-2 10mg $144 2021-12-16 Buy
ChemScene CS-0010193 Cerdulatinib(hydrochloride) 99.54% 1369761-01-2 50mg $480 2021-12-16 Buy
American Custom Chemicals Corporation KIN0002513 4-(CYCLOPROPYLAMINO)-2-[[4-[4-(ETHYLSULFONYL)-1-PIPERAZINYL]PHENYL]AMINO]-5-PYRIMIDINECARBOXAMIDE HYDROCHLORIDE 95.00% 1369761-01-2 5MG $500.01 2021-12-16 Buy
ChemScene CS-0010193 Cerdulatinib(hydrochloride) 99.54% 1369761-01-2 100mg $744 2021-12-16 Buy
Product number Packaging Price Buy
CS-0010193 5mg $108 Buy
CS-0010193 10mg $144 Buy
CS-0010193 50mg $480 Buy
KIN0002513 5MG $500.01 Buy
CS-0010193 100mg $744 Buy

Cerdulatinib HCl salt Chemical Properties,Uses,Production

Biological Activity

Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an orally active multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 for JAK1/JAK2/JAK3/TYK2 and Syk, respectively nM and 32 nM. Also inhibits 19 other kinases tested with IC50s below 200 nM.

in vitro

Cerdulatinib affects BCR-mediated B cell activation through dual inhibition of SYK and JAK in human whole blood from normal donors. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduced cell viability in a subset of NHL cell lines and induced apoptosis in NHL cell lines with BCR signaling.

in vivo

In a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg po) significantly improved inflammatory infiltration of synovium and articular cartilage integrity. In addition, cerdulatinib also blocked BCR-induced B cell activation and splenomegaly in mice.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> ARK5
(Cell-free assay)
TargetValue
TYK2
(Cell-free assay)		 0.5 nM
MST1
(Cell-free assay)		 4 nM
4 nM
MLK1
(Cell-free assay)		 5 nM
Fms
(Cell-free assay)		 5 nM

Cerdulatinib HCl salt Preparation Products And Raw materials

Raw materials

Preparation Products

Cerdulatinib HCl salt Suppliers

Global( 44)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 28251 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323967 +86-18015559028 sales1@artkmedchem.com China 39009 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Supplier Advantage
Hubei Jusheng Technology Co.,Ltd. 		58
BOC Sciences 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Amadis Chemical Company Limited 		58

Cerdulatinib HCl salt Spectrum

Cerdulatinib HCl salt(1369761-01-2)1HNMR

1369761-01-2(Cerdulatinib HCl salt)Related Search:

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1of3

Cerdulatinib HCl salt 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1) Cerdulatinib (PRT062070, PRT2070) Cerdulatinib HCl Cerdulatinib hydrochloride Cerdulatinib HCl salt USP/EP/BP PRT2070 hydrochloride PRT062070 hydrochloride 4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride Cerdulatinib HCl (PRT-2070 1369761-01-2 C20H28ClN7O3S Inhibitors