6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
![6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Structure](CAS/20180703/GIF/361185-42-4.gif)
- CAS No.
- 361185-42-4
- Chemical Name:
- 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
- Synonyms
- RBC8;CS-2130;CS-2174;RBC8, >98%;RBC-8;RBC 8;Inhibitor,RBC 8,Ras,inhibit,RBC8,RBC-8;6-amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;6-amino-4-(2,4-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile;Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-
- CBNumber:
- CB52744624
- Molecular Formula:
- C25H20N4O3
- Molecular Weight:
- 424.45
- MDL Number:
- MFCD03341241
- MOL File:
- 361185-42-4.mol
6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21281 | RBC8 ≥98% | 361185-42-4 | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 21281 | RBC8 ≥98% | 361185-42-4 | 5mg | $104 | 2024-03-01 | Buy |
| Cayman Chemical | 21281 | RBC8 ≥98% | 361185-42-4 | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 21281 | RBC8 ≥98% | 361185-42-4 | 25mg | $401 | 2024-03-01 | Buy |
| Tocris | 5411 | RBC8 ≥98%(HPLC) | 361185-42-4 | 10 | $249 | 2021-12-16 | Buy |
6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Chemical Properties,Uses,Production
Uses
RBC8 is a RalA and RalB inhibitor of the GTPase enzyme, inhibiting binding of Ral to TaLBP1. Used in the treatment and suppression of xenograft tumors, shown in mice.
Biological Activity
rbc8 inhibit ral gtpase with ic50 values of 3.5 μm and 3.4 μm in ral-dependent lines h2122 and h358 [1].rala and b are ras-like gtpases. they are important drivers of metastasis and tumor growth [1].rbc8 reduced the activation of rala in living cells. ral is required for spreading murine embryonic fibroblasts (mefs) and lipid raft exocytosis on fibronectin-coated cover slips. in these cells, the spreading of wt mefs was inhibited by the depletion of rala via sirna, whereas caveolin deficient (cav1-/-) mefs were resistant to rala depletion. treatment with rbc8 inhibited only the cell spreading in the wt mefs, it did not inhibited the cell spreading in cav1-/- mefs. a ral pull-down assay showed that rbc8 inhibited the activation of both rala and ralb in both the h2122 and h358 cell lines. in h2122 and h358 cells with ral knockdown by sirna, treatment with rbc8 did not show further inhibition of colony formation [1].in nude mice inoculated with h2122 human lung cancer cells subcutaneously, treatment with rbc8 at 50 mg/kg/d for 21 days (except weekends) intraperitoneally showed an inhibitory effect on tumor growth to a similar extent as dual knockdown of rala and b. h358 is a lung cancer line. in this cell line, similar results were yielded [1].
storage
Store at -20°C
References
[1]. yan c, liu d, li l, et al. discovery and characterization of small molecules that target the ral gtpase. nature, 2014, 515(7527): 443-447.
6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4604 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4663 | 58 |
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361185-42-4(6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile)Related Search:
6-Amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c ]pyrazole-5-carbonitrile CS-2174 CS-2130 RBC8, >98% RBC-8;RBC 8 6-amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)- Inhibitor,RBC 8,Ras,inhibit,RBC8,RBC-8 361185-42-4 Inhibitors