ChemicalBook >> CAS DataBase List >>E6446 (dihydrochloride)
E6446 (dihydrochloride)
- CAS No.
- 1345675-25-3
- Chemical Name:
- E6446 (dihydrochloride)
- Synonyms
- CS-2089;E6446 HCl;E6446 2HCl;E-6446 DihydrochL;E6446;E 6446;E-6446;E6446 hydrochloride;E6446 (dihydrochloride);E6446 dihydrochloride,E-6446 dihydrochloride;6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride
- CBNumber:
- CB53041403
- Molecular Formula:
- C27H36ClN3O3
- Molecular Weight:
- 486.05
- MDL Number:
- MFCD29472225
- MOL File:
- 1345675-25-3.mol
Last updated:2023-05-18 11:31:12
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| solubility |
DMSO:7.5(Max Conc. mg/mL);14.35(Max Conc. mM) DMF:20.0(Max Conc. mg/mL);38.28(Max Conc. mM) DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.38(Max Conc. mM) Ethanol:2.0(Max Conc. mg/mL);3.83(Max Conc. mM) Water:100.0(Max Conc. mg/mL);191.38(Max Conc. mM) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
E6446 (dihydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 3422DW | E6446(Dihydrochloride) | 1345675-25-3 | 2mg | $147 | 2021-12-16 | Buy |
| AK Scientific | 3422DW | E6446(Dihydrochloride) | 1345675-25-3 | 1g | $1906 | 2021-12-16 | Buy |
| Crysdot | CD31003814 | E6446dihydrochloride 98+% | 1345675-25-3 | 50mg | $2072 | 2021-12-16 | Buy |
| Ambeed | A119560 | E-6446Dihydrochloride 98% | 1345675-25-3 | 1g | $8397 | 2021-12-16 | Buy |
| Arctom | AS439180 | E-6446Dihydrochloride 98% | 1345675-25-3 | 2mg | $176 | 2021-12-16 | Buy |
E6446 (dihydrochloride) Chemical Properties,Uses,Production
Uses
E6446 is a synthetic antagonist of nucleic acid-sensing TLRs. , In vitro, low doses of E6446 specifically inhibited the activation of human and mouse TLR9. Tenfold higher concentrations of this compound also inhibited the human TLR8 response to single-stranded RNA. In vivo, therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection. Furthermore, severe signs of ECM, such as limb paralysis, brain vascular leak, and death, were all prevented by oral treatment with E6446.
E6446 (dihydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 44)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19918 | 55 |
View Lastest Price from E6446 (dihydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | E6446 (dihydrochloride)
1345675-25-3
|
US $1.00 / g | 1g | 99。99% | 200kg | Career Henan Chemical Co |
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- E6446 (dihydrochloride)
1345675-25-3
- US $1.00 / g
- 99。99%
- Career Henan Chemical Co
E6446 (dihydrochloride)
E6446 2HCl
E6446 HCl
E6446 hydrochloride
CS-2089
E6446;E 6446;E-6446
E-6446 DihydrochL
6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride
E6446 dihydrochloride,E-6446 dihydrochloride
1345675-25-3
API