PLX7904
- CAS No.
- 1393465-84-3
- Chemical Name:
- PLX7904
- Synonyms
- 5-(2-cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluorobenzoyl]-1H-pyrrolo[2,3-b]pyridine;PB04;PB-04;PB 04;PLX7904;PLX 7907;PLX7904(PB04);paradox-breaker-04;PLX-7904;PLX 7907;PB04; PB-04; PB 04; PARADOX-BREAKER-04;Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl-
- CBNumber:
- CB53053925
- Molecular Formula:
- C24H22F2N6O3S
- Molecular Weight:
- 512.53
- MDL Number:
- MFCD29472265
- MOL File:
- 1393465-84-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
PLX7904 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20710 | PLX7904 ≥98% | 1393465-84-3 | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 20710 | PLX7904 ≥98% | 1393465-84-3 | 5mg | $166 | 2024-03-01 | Buy |
| Cayman Chemical | 20710 | PLX7904 ≥98% | 1393465-84-3 | 10mg | $275 | 2024-03-01 | Buy |
| Cayman Chemical | 20710 | PLX7904 ≥98% | 1393465-84-3 | 25mg | $581 | 2023-06-20 | Buy |
| AK Scientific | 3018EB | CID90116945 | 1393465-84-3 | 10mg | $403 | 2021-12-16 | Buy |
PLX7904 Chemical Properties,Uses,Production
Biological Activity
plx7904 is a potent and selective braf inhibitor.oncogenic activation of braf leads to cancer growth by constitutively promoting ras-independent mitogen-activated protein kinase pathway signalling. therefore, braf inhibitors have provided substantially improved treatment of metastatic melanoma.
in vitro
previous study showed that plx7904 could inhibit the in-vitro growth of two melanoma cell lines (a375 and colo829) and an additional human colorectal cancer cell line colo205 expressed brafv600e. the gene expression changes in b9 cells treated with vemurafenib and plx7904 were compared, and results demonstrated that vemurafenib could alter transcription of 191 mouse genes by at least 1.9-fold, while plx7904 had minimal effects. moreover, both vemurafenib and its analogue plx4720 werer able to stimulate b9 colony formation, whereas plx7904 was not [1].
in vivo
animal study showed that both plx7904 and vemurafenib could produce similar anti-tumour effects in a subcutaneous colo205 xenograft model with matching doses at 25 mg/kg twice daily and plasma exposures. in addition, when evaluated in vivo, subcutaneous b9-tumour growth was accelerated by vemurafenib but not by plx7904 when administered at the same dose [1].
IC 50
0.17, 0.53, and 0.16 μm for a375, colo829 and colo205 cell lines, respectively.
References
[1] zhang c et al. raf inhibitors that evade paradoxical mapk pathway activation. nature.2015 oct 22;526(7574):583-6.
PLX7904 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18224 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |