ChemicalBook >> CAS DataBase List >>Naquotinib
Naquotinib
- CAS No.
- 1448232-80-1
- Chemical Name:
- Naquotinib
- Synonyms
- ASP-8273;Naquotinib;Naquotinib,ASP-8273;NAQUOTINIB (FREE BASE);Epidermal growth factor receptor,EGFR,ASP 8273,HER1,ErbB-1,ASP-8273,inhibit,Naquotinib,Inhibitor;(R)-5-((1-acryloylpyrrolidin-3-yl)oxy)-6-ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide;6-Ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-2-pyrazinecarboxamide;2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-
- CBNumber:
- CB53062789
- Molecular Formula:
- C30H42N8O3
- Molecular Weight:
- 562.71
- MDL Number:
- MFCD30496701
- MOL File:
- 1448232-80-1.mol
Last updated:2023-09-20 16:43:00
| Boiling point | 717.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.248±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30mg/ml; DMSO: 2 mg/ml; Ethanol: 30mg/ml |
| form | A crystalline solid |
| pka | 14.10±0.50(Predicted) |
| FDA UNII | 47DD4548PB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Naquotinib price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23498 | Naquotinib ≥98% | 1448232-80-1 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 23498 | Naquotinib ≥98% | 1448232-80-1 | 5mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 23498 | Naquotinib ≥98% | 1448232-80-1 | 10mg | $278 | 2024-03-01 | Buy |
| TRC | N378710 | Naquotinib | 1448232-80-1 | 1mg | $80 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611431 | Naquotinib | 1448232-80-1 | 5mg | $569.5 | 2021-12-16 | Buy |
Naquotinib Chemical Properties,Uses,Production
Uses
Naquotinib is an epidermal growth factor receptor (EGFR) inhibitor.
Biological Activity
Naquotinib (ASP8273) is an orally active, irreversible, mutant-selective epidermal growth factor receptor (EGFR) inhibitor with potential antitumor activity.
in vitro
ASP8273 is an irreversible TKI small molecule inhibitor that inhibits the kinase activity of EGFR mutants including T97M with limited activity against wild-type EGFR. In in vitro enzymatic activity and cellular assays, ASP8273 covalently bound to an EGFR mutant (L858R/T790M) through cysteine residues and long-term inhibited EGFR phosphorylation for 24 hours. In NSCLC cell lines with the above-mentioned EGFR mutations, ASP8273 has IC50 values in the range of 8-33 nM for EGFR mutants, more potent than WT EGFR (IC50 for WT EGFR is 230 nM).
target
| Target | Value |
| mutant EGFR |
Naquotinib Preparation Products And Raw materials
Raw materials
Preparation Products
Naquotinib Suppliers
Global( 53)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18224 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
Naquotinib
ASP-8273
6-Ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-2-pyrazinecarboxamide
(R)-5-((1-acryloylpyrrolidin-3-yl)oxy)-6-ethyl-3-((4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide
Naquotinib,ASP-8273
NAQUOTINIB (FREE BASE)
2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-
Epidermal growth factor receptor,EGFR,ASP 8273,HER1,ErbB-1,ASP-8273,inhibit,Naquotinib,Inhibitor
1448232-80-1
448232-80-1