TASP0415914
- CAS No.
- 1292300-75-4
- Chemical Name:
- TASP0415914
- Synonyms
- CS-2671;TSAP0415914;TASP0415914;N-(5-(3-(3-Hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl)-4-methylthiazol-2-yl)acetamide;Acetamide, N-[5-[3-(3-hydroxy-1-piperidinyl)-1,2,4-oxadiazol-5-yl]-4-methyl-2-thiazolyl]-;TASP 0415914,inhibit,inflammatory,PKB,stability,TASP0415914,PI3Kγ,oral,Akt,Phosphoinositide 3-kinase,Protein kinase B,TASP-0415914,Inhibitor,autoimmune,PI3K,metabolic
- CBNumber:
- CB53067582
- Molecular Formula:
- C13H17N5O3S
- Molecular Weight:
- 323.37
- MDL Number:
- MFCD29036384
- MOL File:
- 1292300-75-4.mol
- MSDS File:
- SDS
TASP0415914 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 215892 | TASP-0415914 | 1292300-75-4 | 1mg | $420 | 2021-12-16 | Buy |
| AK Scientific | SYN1208 | TASP0415914 | 1292300-75-4 | 100mg | $2270 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1208-M100 | TASP0415914 ≥95% | 1292300-75-4 | 100mg | $2430 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1208-M005 | TASP0415914 ≥95% | 1292300-75-4 | 5mg | $313 | 2021-12-16 | Buy |
| DC Chemicals | DC8531 | TASP0415914 >98% | 1292300-75-4 | 50mg | $450 | 2021-12-16 | Buy |
TASP0415914 Chemical Properties,Uses,Production
Biological Activity
TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research[1]. TASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes. TASP0415914 has no CYP inhibition up to 10 μM for CYP1A2, 2C9, 2C19, 2D6 and 3A4[1]. TASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model[1].
References
[1]. Yusuke Oka, et al. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem. 2013 Dec 15;21(24):7578-83.
TASP0415914 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 | |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8015 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9833 | 58 |