R-7050
- CAS No.
- 303997-35-5
- Chemical Name:
- R-7050
- Synonyms
- R-7050;R-7050;R 7050;R7050;TNF-α Antagonist III;TNF-α Antagonist III;TNF-alpha Antagonist III, R-7050;8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline;[1,2,4]Triazolo[4,3-a]quinoxaline, 8-chloro-4-(phenylthio)-1-(trifluoromethyl)-;R 7050,Inhibitor,R7050,inhibit,TNFR,Tumor Necrosis Factor Receptor,TNF Receptor,R-7050
- CBNumber:
- CB53152725
- Molecular Formula:
- C16H8ClF3N4S
- Molecular Weight:
- 380.77
- MDL Number:
- MFCD00140737
- MOL File:
- 303997-35-5.mol
R-7050 price More Price(24)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 654257 | TNF-α Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem | 303997-35-5 | 10mg | $201 | 2024-03-01 | Buy |
Cayman Chemical | 16870 | R-7050 ≥95% | 303997-35-5 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 16870 | R-7050 ≥95% | 303997-35-5 | 5mg | $93 | 2024-03-01 | Buy |
Cayman Chemical | 16870 | R-7050 ≥95% | 303997-35-5 | 10mg | $153 | 2024-03-01 | Buy |
Cayman Chemical | 16870 | R-7050 ≥95% | 303997-35-5 | 25mg | $305 | 2024-03-01 | Buy |
R-7050 Chemical Properties,Uses,Production
Uses
R 7050 is a cell permeable TNF-α receptor antagonist.
Biological Activity
ec50: 0.631 μm by tnf-α by icam-1 elisa assayr-7050 is a tnf-α receptor signaling antagonist.tnf-α induces biological activity throgh stimulation of the tumor necrosis factor receptor. although plenty of pre-clinical and clinical evidence suggests a detrimental role, small molecule tnf-αsignaling pathway inhibitors remain largely unexplored in the context of a brain hemorrhage.
in vitro
r-7050 was identified as a selective inhibitot of tnf-α induced cellular signaling by using differential library screening. unlike biologic tnf inhibitors directly binding tnf-α, r-7050 could not affect binding of tnf-α to tnfr. in contrast, r-7050 was able to selectively inhibit the association of tnf receptor with intracellular adaptor molecules [1].
in vivo
in previous animal study, r-7050 was tested to attenuate neurovascular injury after intracerebral hemorrhage (ich) in mice. results showed that up to 2h post-injury administration of r-7050 was able to significantly reduce blood-brain barrier opening and attenuate edema development at 24h post-ich. in addition, neurological outcomes were also improved over the first 3 days after injury. whereas, r-7050 was not found to be albe to reduce hematoma volume, indicating the beneficial effects of tnfr inhibition were downstream of clot formation/resolution [2].
storage
Store at +4°C
References
[1] gururaja tl, yung s, ding r, huang j, zhou x, mclaughlin j, daniel-issakani s, singh r, cooper rd, payan dg, masuda es, kinoshita t. a class of small molecules that inhibit tnfalpha-induced survival and death pathways via prevention of interactions between tnfalphari, tradd, and rip1. chem biol. 2007 oct;14(10):1105-18.
[2] king md, alleyne ch jr, dhandapani km. tnf-alpha receptor antagonist, r-7050, improves neurological outcomes following intracerebral hemorrhage in mice. neurosci lett. 2013 may 10;542:92-6.
R-7050 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
ChemShuttle, Inc. | 0510-83588313-802 18800520310; | sales@chemshuttle.com | China | 3062 | 62 |