2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
- CAS No.
- 79756-69-7
- Chemical Name:
- 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
- Synonyms
- TPI-1;TPI1;TPI 1;TPI-1,Inhibitor,inhibit,Phosphatase;2-(2,5-Dichlorophenyl)-1,4-benzoquinone;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;Recombinant Human TIM/TPI1 Protein, His Tag;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
- CBNumber:
- CB53169525
- Molecular Formula:
- C12H6Cl2O2
- Molecular Weight:
- 253.08
- MDL Number:
- MFCD00448731
- MOL File:
- 79756-69-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2914698090 | |||||||||
| NFPA 704 |
|
2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22480 | TPI-1 ≥95% | 79756-69-7 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 22480 | TPI-1 ≥95% | 79756-69-7 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 22480 | TPI-1 ≥95% | 79756-69-7 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 22480 | TPI-1 ≥95% | 79756-69-7 | 25mg | $573 | 2024-03-01 | Buy |
| Usbiological | 359427 | Tpi1 | 79756-69-7 | 48Tests | $588 | 2021-12-16 | Buy |
2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Chemical Properties,Uses,Production
Biological Activity
TPI-1 (Tyrosine Phosphatase Inhibitor 1) is a potent SHP-1 inhibitor with IC50 of 40 nM for recombinant SHP-1. It has anticancer activity.
in vitro
SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. It selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ + cells and induces IFNγ < sup> + cells in human peripheral blood.
in vivo
TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. It thus also increases pLck-pY394 and IFNγ + cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated sc agent.
target
| Target | Value |
| SHP-1 (Cell-free assay) | 40 nM |
2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |