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MZ 1

MZ 1 structure

CAS No.: 1797406-69-9

Chemical Name:: MZ 1

Synonyms: MZ 1;MZ-1;MZ 1;cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit;L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CBNumber:: CB53367716

Molecular Formula:: C49H60ClN9O8S2

Molecular Weight:: 1002.64

MDL Number:: MFCD30742945

MOL File:: 1797406-69-9.mol

Last updated:2023-06-30 15:45:59

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MZ 1 Properties

Density	1.39±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO:30.0(Max Conc. mg/mL);29.9(Max Conc. mM)
form	A crystalline solid
pka	13.54±0.46(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2934100090

MZ 1 price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3365	MZ1 ≥98% (HPLC)	1797406-69-9	5MG	$114	2024-03-01	Buy
Sigma-Aldrich	SML3365	MZ1 ≥98% (HPLC)	1797406-69-9	25MG	$457	2024-03-01	Buy
Cayman Chemical	21622	MZ1 ≥98%	1797406-69-9	500μg	$48	2024-03-01	Buy
Cayman Chemical	21622	MZ1 ≥98%	1797406-69-9	1mg	$89	2024-03-01	Buy
Cayman Chemical	21622	MZ1 ≥98%	1797406-69-9	5mg	$393	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML3365	5MG	$114	Buy
SML3365	25MG	$457	Buy
21622	500μg	$48	Buy
21622	1mg	$89	Buy
21622	5mg	$393	Buy

MZ 1 Chemical Properties,Uses,Production

Description

MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 μM. At concentrations of 2-10 μM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.

Uses

MZ 1, is a BRD4 protein degrader based on PROTAC technology. The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1.

Definition

ChEBI: MZ1 is an organic molecular entity.

storage

Store at -20°C

MZ 1 Preparation Products And Raw materials

Raw materials

Preparation Products

MZ 1 Suppliers

Global( 57)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai finete Pharmaceutical Co., Ltd.	+86-18221039705		CHINA	139	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	6005	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Supplier	Advantage
Shanghai finete Pharmaceutical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Wuhan Fortuna Chemical Co., Ltd	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58

View Lastest Price from MZ 1 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-09-29	MZ 1 1797406-69-9	US $0.00 / mg	1mg	98%min	500mg	WUHAN FORTUNA CHEMICAL CO., LTD

MZ 1
1797406-69-9
US $0.00 / mg
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

MZ 1 (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide MZ-1;MZ 1 L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- (2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit 1797406-69-9 C49H60ClN9O8S2