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ChemicalBook >> CAS DataBase List >>4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide

4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide

4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide Structure
4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide structure
CAS No.
1117684-36-2
Chemical Name:
4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide
Synonyms
AZ12799734;4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide;Benzenesulfonamide, 4-[[4-[(2,6-dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]-
CBNumber:
CB53385192
Molecular Formula:
C18H18N4O3S
Molecular Weight:
370.43
MDL Number:
MFCD26397939
MOL File:
1117684-36-2.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
FDA UNII H6YYY77937

4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2819 AZ12799734 ≥98% (HPLC) 1117684-36-2 5MG $102 2023-06-20 Buy
Sigma-Aldrich SML2819 AZ12799734 ≥98% (HPLC) 1117684-36-2 25MG $408 2023-06-20 Buy
Tocris 6870 AZ12799734 ≥98%(HPLC) 1117684-36-2 10 $205 2021-12-16 Buy
Product number Packaging Price Buy
SML2819 5MG $102 Buy
SML2819 25MG $408 Buy
6870 10 $205 Buy

4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide Chemical Properties,Uses,Production

Biochem/physiol Actions

AZ12799734 is an orally active TGF-β type I receptors active site inhibitor (ALK1/2/3/4/5/6 Kd = 7.1/6.2/40/1/0.74/0.017 μM) that inhibits ALK5-dependent Smad2 nuclear translocation upon TGF-β1 stimulation (IC50 = 17 nM; MDA-MB-468), as well as ALK1/2/3/6-mediated Smad1 and ALK4/5/7-mediated Smad2 phosphorylation (10 μM; NIH3T3 expressing respective constitutively active receptors). AZ12799734 oral administration in rats results in heart valve lesions (200 mg/kg/day for 5 days) and physeal dysplasia (400 mg/kg/day for 6 days), consistent with a critical role of ALK5 in maintaining the integrity of heart valve and physis.

storage

Store at -20°C

4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 361 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4249 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Aladdin Scientific 		58
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai Hongye Biotechnology Co. Ltd 58
Changzhou Furuisi Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide AZ12799734 Benzenesulfonamide, 4-[[4-[(2,6-dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]- 1117684-36-2