Pemigatinib
- CAS No.
- 1513857-77-6
- Chemical Name:
- Pemigatinib
- Synonyms
- IBI-375;INCB54828;INCB 54828;INCB-54828;INCB-054828;Pemigatinib;2H8]-Pemigatinib;Terbufos Impurity 14 (Ethion);INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic;3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
- CBNumber:
- CB54796678
- Molecular Formula:
- C24H27F2N5O4
- Molecular Weight:
- 487.5
- MDL Number:
- MFCD31706227
- MOL File:
- 1513857-77-6.mol
Boiling point | 697.6±55.0 °C(Predicted) |
---|---|
Density | 1.44±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO:40.0(Max Conc. mg/mL);82.05(Max Conc. mM) |
form | A crystalline solid |
pka | 11.56±0.40(Predicted) |
NCI Dictionary of Cancer Terms | pemigatinib |
FDA UNII | Y6BX7BL23K |
NCI Drug Dictionary | pemigatinib |
ATC code | L01EX20 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
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Pemigatinib price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0039499 | Pemigatinib 99.88% | 1513857-77-6 | 5mg | $120 | 2021-12-16 | Buy |
ChemScene | CS-0039499 | Pemigatinib 99.88% | 1513857-77-6 | 10mg | $190 | 2021-12-16 | Buy |
ChemScene | CS-0039499 | Pemigatinib 99.88% | 1513857-77-6 | 25mg | $350 | 2021-12-16 | Buy |
ChemScene | CS-0039499 | Pemigatinib 99.88% | 1513857-77-6 | 50mg | $550 | 2021-12-16 | Buy |
ChemScene | CS-0039499 | Pemigatinib 99.88% | 1513857-77-6 | 100mg | $950 | 2021-12-16 | Buy |
Pemigatinib Chemical Properties,Uses,Production
Binding Mode
Pemigatinib binds to the inactive conformation
of FGFR1 with the activation loop adopting a DFG-in
conformation (type I1/2 inhibitor). The
pyrrolopyridine moiety forms two hydrogen bonds
with the NH and the carbonyl of Ala564 in the hinge
region (Figs. 3, 4). The difluoromethoxyphenyl ring,
which is perpendicular relative to the tricyclic ring, fits
the specificity pocket containing the gatekeeper
residue Val561. One of the methoxy oxygen atoms
hydrogen bonds to the backbone NH of Asp641. The
terminal morpholine extends towards the solventfront region, and makes only minor contacts with the
protein.
Uses
Pemigatinib is a potent inhibitor of FGFRs for the treatment of cholangiocarcinoma.
Indications
Pemigatinib is indicated for the treatment of previously treated adult patients with unresectable locally advanced or metastatic cholangiocarcinoma (CCA) who have been identified by an FDA-approved test for the presence of fibroblast growth factor receptor 2 (FGFR2) fusions or other rearrangements.
brand name
Pemazyre
General Description
Class: receptor tyrosine kinase; Treatment: metastatic cholangiocarcinoma; Other name: INCB054828; Elimination half-life = 15 h; Protein binding = 90.6%
target
Primary targets: Pan-FGFR
IC 50
FGFR1/2/3/4 IC 50 = 0.4, 0.5, 1, 30 nM
Pemigatinib Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Pemigatinib Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Beijing Mesochem Technology Co.,Ltd | +8613651027935 | rachel@mesochem.com | China | 191 | 58 |
Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 882 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 8472 | 58 |
Related articles
- How is Pemigatinib Synthesised?
- Pemigatinib is synthesised using pyrrolopyridine as a raw material, firstly by synthesis of Pemigatinib Morpholine Intermediat....
- Jan 2,2024
View Lastest Price from Pemigatinib manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-05-09 | Pemigatinib
1513857-77-6
|
US $0.00-0.00 / kg | 1kg | 99%, Single impurity<0.1 | 1 ton | Nanjing Fred Technology Co., Ltd | ||
2023-11-27 | Pemigatinib
1513857-77-6
|
US $0.00-0.00 / mg | 10mg | 98% | 50kg | Wuhan Senwayer Century Chemical Co.,Ltd |
- Pemigatinib
1513857-77-6
- US $0.00-0.00 / kg
- 99%, Single impurity<0.1
- Nanjing Fred Technology Co., Ltd
- Pemigatinib
1513857-77-6
- US $0.00-0.00 / mg
- 98%
- Wuhan Senwayer Century Chemical Co.,Ltd