5-Aminouridine
- CAS No.
- 2149-76-0
- Chemical Name:
- 5-Aminouridine
- Synonyms
- 5-aminouridine;Uridine, 5-amino-;5-Aminouridine Hcl;5-AminouridineHClsalt;Uridine, 5-amino-(6CI,7CI,8CI,9CI);5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;5-azanyl-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;5-amino-1-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidine-2,4-quinone;5-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
- CBNumber:
- CB5496873
- Molecular Formula:
- C9H13N3O6
- Molecular Weight:
- 259.22
- MDL Number:
- MFCD00038055
- MOL File:
- 2149-76-0.mol
- MSDS File:
- SDS
| Melting point | 214-216 °C |
|---|---|
| Density | 1.712±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| pka | 9.31±0.10(Predicted) |
| InChI | InChI=1S/C9H13N3O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2,10H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1 |
| InChIKey | YBTWWWIJBCCYNR-UAKXSSHOSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(N)C(=O)NC2=O)[C@H](O)[C@@H]1O |
5-Aminouridine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD70001702 | 5-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 95+% | 2149-76-0 | 250mg | $300 | 2021-12-16 | Buy |
| Chemenu | CM322243 | 5-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 95% | 2149-76-0 | 1g | $701 | 2021-12-16 | Buy |
| Crysdot | CD70001702 | 5-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 95+% | 2149-76-0 | 1g | $750 | 2021-12-16 | Buy |
5-Aminouridine Chemical Properties,Uses,Production
Description
5-Aminouridine can modify nucleobases and can be incorporated into the target DNA. 5-Aminouridine exhibits a wide range of biological activity and it inhibits the growth of tumors, fungi and viruses.
in vitro
This modified nucleobase, 5-Aminouridine, must exhibit a low enough potential to be oxidized by Os(bpy)33+. These modified nucleobases can be inserted into the target DNA by direct synthesis using modified phosphoramidites
in vivo
5-Aminouridine inhibits the incorporation of carbamyl aspartate into pyrimidines of both RNA and DNA in rat lived and [32P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma. 5-Aminouridine was found to be incorporated into the RNA of Ehrlich ascites cells, and 5-aminouridine monophosphate was shown to be a strong inhibitor of orotidine 5'-phosphate decarboxylase[1].
References
[1] David A. Smith, Donald W. Visser, P. Roy-Burman. “Studies on 5-aminouridine.” Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 119 2 (1966): Pages 221-228.
5-Aminouridine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Aminouridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD | 0371-55159968 18137130222 | haifeng.zhang@pannacean.com | China | 409 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9976 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9900 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9767 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |