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NADPH

NADPH Structure
NADPH structure
CAS No.
53-57-6
Chemical Name:
NADPH
Synonyms
NADPN;NADPH2;reduced;Na4 salt;ent-NADPH;β-NADPH-d4;Reduced Co II;Triphosphopyridine Nu;Dihydrocodehydrogenase II;dihydrotriphosphopyridine nucleotide
CBNumber:
CB5501007
Molecular Formula:
C21H30N7O17P3
Molecular Weight:
745.42
MDL Number:
MFCD00674870
MOL File:
53-57-6.mol
MSDS File:
SDS
Last updated:2024-04-29 10:24:55
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NADPH Properties

Boiling point 1175.1±75.0 °C(Predicted)
Density 2.28±0.1 g/cm3(Predicted)
pka 1.13±0.50(Predicted)
FDA UNII 381Q4X082D
EPA Substance Registry System Nicotinamide adenine dinucleotide phosphate (53-57-6)

NADPH price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC N201504 β-NADPH-d4 53-57-6 5mg $21725 2021-12-16 Buy
Product number Packaging Price Buy
N201504 5mg $21725 Buy

NADPH Chemical Properties,Uses,Production

Uses

One of the biologically active forms of nicotinic acid. Differs from NAD by an additional phosphate group at the 2?position of the adenosine moiety. Serves as a coenzyme of hydrogenases and dehydrogenases. Present in living cells primarily in the r

Uses

β-NADPH-d4 is the isotope labelled analog of β-NADPH. One of the biologically active forms of nicotinic acid. Differs from NAD by an additional phosphate group at the 2’-position of the adenosine moiety. Serves as a coenzyme of hydrogenases and dehydrogenases. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions.

Definition

A coenzyme composed of ribosylnicotinamide 5′- phosphate coupled by pyrophosphate linkage to the 5′-phosphate adenosine 2′,5′-bisphosphate. The reduced from of NADP. It is an energy-storage form that can be transferred to the Calvin cycle where it participates in the production of carbohydrate.

Biological Functions

Nicotinamide adenine dinucleotide phosphate (NADPH) is used to maintain reduced glutathione (GSH) and thioredoxin (TRX). It is also well known as an essential electron donor and an indispensable cofactor for transferring and reserving reduction potential for numerous anabolic reactions. A growing body of evidence has shown that regeneration and maintenance of the cellular NADP(H) content is strongly implicated in various pathological conditions, such as diabetes, cardiovascular disease, neurodegenerative diseases, and aging, especially in tumorigenesis and cancer progression. Compared with non-tumor cells, tumor cells usually maintain high levels of NADPH to power redox defense and use biosynthetic reactions to sustain their rapid growth[1].

Biochem/physiol Actions

NADPH is predominantly bound to intracellular proteins with different affinities. The intracellular content of NADP(H) differs markedly among tissues and cell types. For instance, the total NADP(H) is about 420?nmol/g wet weight in rat liver 59% of total NADP(H) is found in mitochondria, and 30?nmol/g wet weight in skeletal muscle, and the NADPH concentration in the cytosol is 3.1?±?0.3 and 37?±?2?μM in the mitochondrial matrix in HeLa cells. In addition, the redox potentials of the mitochondrial and cytosolic NADP(H) systems are the same, around—400?mV in the liver[1].

References

[1] Huai-Qiang Ju. “NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications.” Signal Transduction and Targeted Therapy (2020): 231.

NADPH synthesis

1094-61-7
56-65-5
53-57-6
Synthesis of NADPH from β-Nicotinamide Mononucleotide and Adenosine triphosphate

NADPH Preparation Products And Raw materials

Raw materials

i-Propylcyclopentadienylrhenium tricarbonyl dihydronicotinamide-adenine dinucleotide β-Nicotinamide adenine dinucleotide β-Nicotinamide Mononucleotide Triphosphopyridine nucleotide
Adenosine triphosphate

1of2

Preparation Products

5-amino-2,5-dioxo-pentanoic acid

NADPH Suppliers

Global( 23)Suppliers
Supplier Tel Email Country ProdList Advantage
Maintain Biotech Co., Ltd.
+86-75589664337 +86-15112661142 cami@maintain-bio.com China 66 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12471 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 28455 58
Hong Kong Tiansheng New Material Trading Co., Ltd 		+8617320695765 zxx@hktiansheng.com China 981 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503259 +86-19930503259 cherry@crovellbio.com China 18451 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Maintain Biotech Co., Ltd. 755-89664337 19125366885 sales@maintain-bio.com China 51 58
Suzhou Shunyixiang Biotechnology Co., Ltd 15973717224 526868882@qq.com China 6 58
Shanghai Ruji Biology Technology Co., Ltd. +86-21-65211385-8001 36031160 sales@shruji.com China 3224 55
Supplier Advantage
Maintain Biotech Co., Ltd.
58
Hebei Mojin Biotechnology Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58
Dideu Industries Group Limited 		58
Hong Kong Tiansheng New Material Trading Co., Ltd 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
LEAPCHEM CO., LTD. 		58
Maintain Biotech Co., Ltd. 58
Suzhou Shunyixiang Biotechnology Co., Ltd 58
Shanghai Ruji Biology Technology Co., Ltd. 55

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View Lastest Price from NADPH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ent-NADPH pictures 2023-10-14 ent-NADPH
53-57-6
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
ent-NADPH pictures 2023-09-06 ent-NADPH
53-57-6
 US $0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
ent-NADPH pictures 2022-03-31 ent-NADPH
53-57-6
 US $7.60 / KG 1KG 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd
  • ent-NADPH pictures
  • ent-NADPH
    53-57-6
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • ent-NADPH pictures
  • ent-NADPH
    53-57-6
  • US $0.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.
  • ent-NADPH pictures
  • ent-NADPH
    53-57-6
  • US $7.60 / KG
  • 99%
  • Hong Kong Tiansheng New Material Trading Co., Ltd

NADPH Spectrum

25 MG -NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED.NA4-SALT AN.GR.(53-57-6)IR1

53-57-6(NADPH)Related Search:

Adenine phosphate salt（1：1） Triphosphopyridine nucleotide
25 MG ?-NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED.NA4-SALT AN.GR. adenosine5’-(trihydrogendiphosphate),2’-(dihydrogenphosphate),p’.fwdarw.5’ -esterwith1,4-dihydro-1-beta-d-ribofuranosyl-3-pyridinecarboxamide dihydronicotinamide-adenine dinucleotide phosphate dihydrotriphosphopyridine nucleotide Adenosine 5-(trihydrogen diphosphate), 2-(dihydrogen phosphate), P?5-ester with 1,4-dihydro-1-.beta.-D-ribofuranosyl-3-pyridinecarboxamide [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methyl [[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate Adenosine 5'-(Trihydrogen Diphosphate) 2'-(Dihydrogen Phosphate) P'-5'-Ester with 1,4-Dihydro-1--D-ribofuranosyl-3-pyridinecarboxamide Dihydrocodehydrogenase II -Nicotinamide-adenine-dinucleotide-phosphoric Acid Triphosphopyridine Nu NADPH2 Reduced Co II Reduced triphosphopyridine nucleotide [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methyl [[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] hydrogen phosphate [[(2R,3S,4R,5R)-5-(3-aminocarbonyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] [(2R,3R,4R,5R)-5-(6-azanylpurin-9-yl)-3-hydroxy-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate Na4 salt reduced 25 MG -NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED.NA4-SALT AN.GR. USP/EP/BP β-NADPH-d4 ent-NADPH NADPN Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'→5'-ester with 1,4-dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide NADPH,NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED β-Nicotinamide adenine dinucleotide phosphate Reduced form 53-57-6 C21H30N7O17P3 Bases & Related Reagents Carbohydrates & Derivatives Nucleotides Phosphorylating and Phosphitylating Agents