2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]-
![2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- Structure](CAS/20210305/GIF/859518-94-8.gif)
- CAS No.
- 859518-94-8
- Chemical Name:
- 2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]-
- Synonyms
- T0467;N-[2-(3,5-difluorophenyl)ethyl]-4-(2-fluoro-5-{[(2S)- 2-methylpiperazin-1-yl]methyl}phenyl)pyrimidin-2- amine;2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]-
- CBNumber:
- CB59811259
- Molecular Formula:
- C24H26F3N5
- Molecular Weight:
- 441.49
- MDL Number:
- MOL File:
- 859518-94-8.mol
2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- Properties
| Boiling point | 570.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.251±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 33.33 mg/mL (75.49 mM; Need ultrasonic) |
| pka | 9.14±0.40(Predicted) |
2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- Chemical Properties,Uses,Production
Biological Activity
T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson’s disease and related disorders research[1]. T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells[1]. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells[1].T0467 does not show obvious toxicity in Drosophila at concentrations Drosophila larval muscles[1].
References
[1]. Kahori Shiba-Fukushima, et al. A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling. iScience. 2020 May 22;23(5):101048.
2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- Suppliers
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| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | info@synzest.com | China | 9287 | 58 |
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