Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosyl-
- CAS No.
- 91032-26-7
- Chemical Name:
- Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosyl-
- Synonyms
- MDL-507;Targosid;Targocid;teicoplanin A2-2;Teicoplanin A2-2 DISCONTINUED. Please see T015500;Ristomycin A aglycone, 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-;Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosyl-
- CBNumber:
- CB61215184
- Molecular Formula:
- C88H97Cl2N9O33
- Molecular Weight:
- 1879.66
- MDL Number:
- MFCD01750325
- MOL File:
- 91032-26-7.mol
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosyl- Properties
| Melting point | 2500C (dec.) |
|---|---|
| Density | 1.68±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | Methanol (Slightly) |
| pka | 2.88±0.40(Predicted) |
| form | Solid |
| color | Off-White |
| FDA UNII | 9V7Z6HDK93 |
| NCI Drug Dictionary | Targocid |
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosyl- price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16096 | Teicoplanin A2-2 ≥90% | 91032-26-7 | 5mg | $45 | 2021-12-16 | Buy |
| Cayman Chemical | 16096 | Teicoplanin A2-2 ≥90% | 91032-26-7 | 10mg | $86 | 2021-12-16 | Buy |
| Cayman Chemical | 16096 | Teicoplanin A2-2 ≥90% | 91032-26-7 | 25mg | $146 | 2021-12-16 | Buy |
| Cayman Chemical | 16096 | Teicoplanin A2-2 ≥90% | 91032-26-7 | 50mg | $225 | 2021-12-16 | Buy |
| ApexBio Technology | C3940 | TeicoplaninA2-2 | 91032-26-7 | 50mg | $312 | 2021-12-16 | Buy |
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosyl- Chemical Properties,Uses,Production
Chemical Properties
White Amorphous Powder
Uses
Teicoplanin A2-2 is a useful compound to analyze the effect of hydrophobic substituents in the biological activity of glycopeptide antibiotics. It has also been used to synthesize teicoplanin derivatives that may overcome antibiotic resistance.
Uses
Glycopeptide antibiotic complex produced by Actinoplanes teichomyceticus; structurally related to vancomycin. Comprised of 5 major components differentiated by a specific fatty acid moiety. Inhibits peptidoglycan synthesis in the cell wall of gram-positive bacteria.
Uses
Teicoplanin A2-2 is a major analogue of a family of lipoglycopeptides produced by Actinoplanes teichomyceticus which possesses potent broad spectrum antibiotic activity against Gram positive bacteria, including MRSA and E. faecalis.
Definition
ChEBI: A teicoplanin A2 that has 8-methylnonanoyl as the variable N-acyl group.
Biological Activity
teicoplanin a2-2 is a new glycopeptide antibiotic belonging to the same family as vancomycin. teicoplanin consists of five major components (a2-1 through a2-5), one hydrolysis component (a3-1), and four minor components (rs-1 through rs-4) [1]. teicoplanin is isolated from the fermentation broth of actinoplanes teichomyceticus nov. sp. and has been endowed with outstanding bactericidal activity against grampositive pathogenic bacteria [2].[1] bernareggi a, borghi a, borgonovi m, et al. teicoplanin metabolism in humans[j]. antimicrobial agents and chemotherapy, 1992, 36(8): 1744-1749.[2] s. somma, l. gastaldo and a. corti. teicoplanin, a new antibiotic from actinoplanes teichomyceticus nov. sp. antimicrobial agents and chemotherapy 26(6), 917-923 (1984).[3] rowland m. clinical pharmacokinetics of teicoplanin[j]. clinical pharmacokinetics, 1990, 18(3): 184-209.
in vitro
teicoplanin inhibited cell wall synthesis in bacillus subtilis, the inhibition is accompanied by an intracellular accumulation of udp-n-acetyl-muramyl-pentapeptide. in a cell-free system from bacillus stearothermophilus, treatment with teicoplanin (40 μg/ml) inhibited 50% of peptidoglycan synthesis, and 100 μg/ml teicoplanin totally suppressed peptidoglycan synthesis [2].
in vivo
following intravenous administration, concentrations of teicoplanin were high in lung and bone tissue and low in fat in relative to those in plasma in patients with normal renal function. animal data showed high concentrations in most tissues, and particularly high in liver and kidneys [3].
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosyl- Preparation Products And Raw materials
Raw materials
Preparation Products
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxononyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17993 | 56 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55936 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| Alfa Chemistry | 58 |
| J & K SCIENTIFIC LTD. | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 50 |
| Clearsynth Labs Limited | 58 |
| ChemStrong Scientific Co.,Ltd | 56 |
| BOC Sciences | 65 |
| Lynnchem | 58 |
| Novachemistry | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | 58 |