ChemicalBook >> CAS DataBase List >>INCB8761(PF-4136309)
INCB8761(PF-4136309)
- CAS No.
- 1341224-83-6
- Chemical Name:
- INCB8761(PF-4136309)
- Synonyms
- CS-1440;EOS-61910;NCB8761(PF-4136309);INCB8761(PF-4136309);PF-04136309(INCB-8761);ZNSVOHSYDRPBGI-LXWOLXCRSA-N;N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL);INCB8761; PF-4136309; PF4136309; PF 4136309; INCB-8761;INCB-8761,INCB 8761,inhibit,PF-4136309,CC chemokine receptor,CCR,Inhibitor,PF4136309;N-(2-((S)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
- CBNumber:
- CB62627975
- Molecular Formula:
- C29H31F3N6O3
- Molecular Weight:
- 568.59
- MDL Number:
- MOL File:
- 1341224-83-6.mol
Last updated:2023-06-08 09:02:51
| Boiling point | 712.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| form | solid |
| pka | 13.17±0.46(Predicted) |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | 3M2595V4KT |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
INCB8761(PF-4136309) price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21965 | INCB 8761 | 1341224-83-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21965 | INCB 8761 | 1341224-83-6 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 21965 | INCB 8761 | 1341224-83-6 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 21965 | INCB 8761 | 1341224-83-6 | 25mg | $533 | 2024-03-01 | Buy |
| ChemScene | CS-0610 | PF-4136309 99.59% | 1341224-83-6 | 100mg | $760 | 2021-12-16 | Buy |
INCB8761(PF-4136309) Chemical Properties,Uses,Production
Description
PF-4136309 is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50s = 5.2, 13, and 17 nM for the human, rat, and mouse receptors, respectively). It also inhibits the voltage-gated potassium channel subtype Kv11.1 by 35% when used at a concentration of 10 μM. PF-4136309 decreases isolated human monocyte chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 3.9 nM.
Uses
PF 4136309 is a CCR5 receptor antagonists that contributes to the treatment of rheumatoid arthritis.
References
1) Chu-Biao?et al.?(2011),?Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist;?ACS Med. Chem. Lett.?2?913 2) Sanford?et al.?(2013),?Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis;?Clin. Cancer Res.?19?3404 3) Nywenig?et al.?(2016),?Phase 1b study targeting tumor associated macrophages with CCR2 inhibition plus FOLFIRINOX in locally advanced and borderline resectable pancreatic cancer;?Lancet Oncol.?17?651
INCB8761(PF-4136309) Preparation Products And Raw materials
Raw materials
8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol
4-hydroxy-4-(5-(pyrimidin-2-yl)pyridine-2-yl) cyclohexanone
8-(5-(pyrimidin-2-yl)pyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol
2-[3-(Trifluoromethyl)benzoyl]aminoacetic acid
Benzamide, N-[2-[(3S)-3-amino-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-, hydrochloride (1:1)
1of2
Preparation Products
Global( 88)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18223 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
1341224-83-6(INCB8761(PF-4136309))Related Search:
INCB8761(PF-4136309)
NCB8761(PF-4136309)
PF-04136309(INCB-8761)
Benzamide, N-[2-[(3S)-3-[[trans-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-
EOS-61910
N-(2-((S)-3-(((1r,4S)-4-hydroxy-4-(5-(pyrimidin-2-yl) yridine-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
ZNSVOHSYDRPBGI-LXWOLXCRSA-N
N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL)
CS-1440
INCB8761; PF-4136309; PF4136309; PF 4136309; INCB-8761
N-(2-((S)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
INCB-8761,INCB 8761,inhibit,PF-4136309,CC chemokine receptor,CCR,Inhibitor,PF4136309
1341224-83-6