MK-6892
- CAS No.
- 917910-45-3
- Chemical Name:
- MK-6892
- Synonyms
- MK-6892;CS-2425;MK 6892;MK6892;HCAR2,PUMA-G,MK-6892,HM74A,HCA2,Inhibitor,GPR109A,MK6892,inhibit,MK 6892;2-[[3-[3-(5-Hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethyl-1-oxopropyl]amino]-1-cyclohexene-1-carboxylic acid;1-Cyclohexene-1-carboxylic acid, 2-[[3-[3-(5-hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethyl-1-oxopropyl]amino]-
- CBNumber:
- CB62628149
- Molecular Formula:
- C19H22N4O5
- Molecular Weight:
- 386.4
- MDL Number:
- MFCD20528236
- MOL File:
- 917910-45-3.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | ≥34.9 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| FDA UNII | PH9ZB6IRW0 |
MK-6892 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1480 | MK-6892 99.43% | 917910-45-3 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-1480 | MK-6892 99.43% | 917910-45-3 | 10mg | $456 | 2021-12-16 | Buy |
| ApexBio Technology | A3623 | MK-6892 | 917910-45-3 | 10mg | $557 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014020 | MK-6892 95.00% | 917910-45-3 | 0.1G | $723 | 2021-12-16 | Buy |
| ChemScene | CS-1480 | MK-6892 99.43% | 917910-45-3 | 50mg | $1080 | 2021-12-16 | Buy |
MK-6892 Chemical Properties,Uses,Production
Biological Activity
mk-6892 is a highly potential gpr109a agonists.
in vitro
despite the increased serum shift of these compounds, the representative 1e was highly potent. furthermore, these compounds had no activity on gpr109b and gpr81, the two most closely related gpcrs with 96% and 50% sequence identity to gpr109a,respectively [1].
in vivo
na or mk-6892 was orally administered to wt or na receptor null mice on the same c57bl/6 genetic background. after 15 min of 100 mpk dosing of na or mk-6892 to fed wt or na receptor null mice, the blood levels of mk-6892 at 15 min were 229 μm (950-fold greater than the in vitro ec50 determined in mouse na receptor gtpγs assay, which is 240 nm) in wt mice and 148 μm (620-fold greater than the in vitro ec50) in na receptor null mice [1].
IC 50
ic50 value: 4.0 nm (ki for human gpr109a) [1]
MK-6892 Preparation Products And Raw materials
Raw materials
Preparation Products
MK-6892 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25014 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Codow Chemical Co.,Ltd. | 18620099427 | amy@howeipharm.com | China | 17698 | 55 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| Chengdu Dianchun Technology Co., Ltd | 400-1166-196 18502815961 | cdhxsj@163.com | China | 14623 | 60 |