Takeda-6d
- CAS No.
- 1125632-93-0
- Chemical Name:
- Takeda-6d
- Synonyms
- CS-2670;Takeda-6d;TAKEDA 6D;TAKEDA6D;Benzamide, 2-chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)amino]thiazolo[5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]-;2-Chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)aMino][1,3]thiazolo[5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]benzaMide;antitumor,HUVEC cells,VEGFR,inhibit,antiangiogenesis,Raf,Vascular endothelial growth factor receptor,PKR-like endoplasmic reticulum kinase,orally active,Takeda-6D,Inhibitor,Takeda 6d,PERK,Takeda6d,Raf kinases,Protein kinase R-like endoplasmic reticulum kinase
- CBNumber:
- CB62642552
- Molecular Formula:
- C27H19ClFN5O3S
- Molecular Weight:
- 547.99
- MDL Number:
- MFCD25977105
- MOL File:
- 1125632-93-0.mol
- MSDS File:
- SDS
Takeda-6d price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1168-M001 | Takeda-6d ≥95% | 1125632-93-0 | 1mg | $211 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0002082 | TAKEDA-6D 95.00% | 1125632-93-0 | 5MG | $498.94 | 2021-12-16 | Buy |
| DC Chemicals | DC10065 | Takeda-6d >98% | 1125632-93-0 | 25mg | $600 | 2021-12-16 | Buy |
| DC Chemicals | DC10065 | Takeda-6d >98% | 1125632-93-0 | 10mg | $350 | 2021-12-16 | Buy |
Takeda-6d Chemical Properties,Uses,Production
Biological Activity
Takeda-6d is a dual inhibitor of RAF kinases and VEGFR2.1 It inhibits wild-type B-RAF, mutant B-RAFV600E, and C-RAF (IC50s = 12, 7, and 1.5 nM, respectively), as well as VEGFR2 (IC50 = 2.8 nM). Takeda-6d is selective for these kinases over a panel of 19 additional kinases (IC50s = >1,000 nM) but does inhibit FGFR3, PDGFRα, and PDGFRβ (IC50s = 22, 12, and 5.5 nM, respectively). It inhibits MEK and ERK1/2 phosphorylation in several colon cancer and melanoma cell lines expressing B-RAFV600E when used at concentrations ranging from 100 to 1,600 nM, as well as inhibits VEGF-A-induced phosphorylation of VEGFR2 in VEGFR2-overexpressing KDR cells (IC50 = 0.53 nM). Takeda-6d (10 mg/kg) reduces tumor volume in an A375 melanoma mouse xenograft model.
References
1.Okaniwa, M., Hirose, M., Imada, T., et al.Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffoldsJ. Med. Chem.55(7)3452-3478(2012)
Takeda-6d Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| SYN|thesis med chem P/L | +86-021-50720296 | service@synkinase.com | China | 266 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9756 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |