ChemicalBook >> CAS DataBase List >>APD668
APD668
- CAS No.
- 832714-46-2
- Chemical Name:
- APD668
- Synonyms
- APD668;CS-1179;APD 668, >=98%;APD 668; APD-668;4-[[1-(2-Fluoro-4-methylsulfonylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylic acid isopropyl ester;1-Piperidinecarboxylic acid,4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-, 1-methylethyl ester;Inhibitor,CYPs,APD668,diabetes,Cytochrome P450,APD-668,GPR119,Potassium Channel,coupled,G-protein,steatohepatitis,CYP2C9,G Protein-Coupled Receptor 119,inhibit,KcsA;isopropyl 4-((1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)piperidine-1-carboxylate APD668;APD668 ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE
- CBNumber:
- CB62667083
- Molecular Formula:
- C21H24FN5O5S
- Molecular Weight:
- 477.51
- MDL Number:
- MFCD12032117
- MOL File:
- 832714-46-2.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:03:09
| Boiling point | 611.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥17.4 mg/mL in DMSO; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| pka | 2.13±0.30(Predicted) |
| FDA UNII | JC77BCH2AP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
APD668 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17642 | APD668 ≥98% | 832714-46-2 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17642 | APD668 ≥98% | 832714-46-2 | 5mg | $202 | 2024-03-01 | Buy |
| Cayman Chemical | 17642 | APD668 ≥98% | 832714-46-2 | 10mg | $363 | 2024-03-01 | Buy |
| TRC | A726235 | APD668 | 832714-46-2 | 10mg | $265 | 2021-12-16 | Buy |
| TRC | A726235 | APD668 | 832714-46-2 | 25mg | $530 | 2021-12-16 | Buy |
APD668 Chemical Properties,Uses,Production
Uses
APD 668 is a potent agonist of GPR119, a glucose-dependant insulinotropic receptor expressed in pancreatic β-cells and intestinal L-cells.
References
[1]. semple g, ren a, fioravanti b, et al. discovery of fused bicyclic agonists of the orphan g-protein coupled receptor gpr119 with in vivo activity in rodent models of glucose control. bioorg med chem lett, 2011, 21(10):3134-41.
[2]. soga t, ohishi t, matsui t, et al. lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan g-protein-coupled receptor. biochem biophys res commun, 2005, 326(4):744-51.
[3]. overton ha, babbs aj, doel sm, et al. deorphanization of a g protein coupled receptor for oleoylethanolamide and its use in the discovery of small molecule hypophagic agents. cell metab, 2006, 3(3):167-75.
APD668 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 79)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
View Lastest Price from APD668 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE pictures](https://img.chemicalbook.com/ProductImageEN/2019-9/Small/aa1992c2-81fe-48c3-ae40-3b3adb0ce3d7.jpg) |
2019-09-05 | ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE
832714-46-2
|
US $1.00 / ASSAYS | 1ASSAYS | 98% | 10kg | Career Henan Chemical Co |
-
- ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE
832714-46-2
- US $1.00 / ASSAYS
- 98%
- Career Henan Chemical Co
APD668
APD668 ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE
isopropyl 4-((1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)piperidine-1-carboxylate APD668
APD 668, >=98%
4-[[1-(2-Fluoro-4-methylsulfonylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylic acid isopropyl ester
1-Piperidinecarboxylic acid,4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-, 1-methylethyl ester
APD 668; APD-668
CS-1179
Inhibitor,CYPs,APD668,diabetes,Cytochrome P450,APD-668,GPR119,Potassium Channel,coupled,G-protein,steatohepatitis,CYP2C9,G Protein-Coupled Receptor 119,inhibit,KcsA
832714-46-2
C21H24FN5O5S
Inhibitors