3-methyl toxoflavin
- CAS No.
- 32502-62-8
- Chemical Name:
- 3-methyl toxoflavin
- Synonyms
- 3-methyl toxoflavin;1,3,6-Trimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione;Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,3,6-trimethyl-;Inhibitor,3 Methyltoxoflavin,3-Methyltoxoflavin,3Methyltoxoflavin,inhibit
- CBNumber:
- CB63041187
- Molecular Formula:
- C8H9N5O2
- Molecular Weight:
- 207.19
- MDL Number:
- MFCD00449892
- MOL File:
- 32502-62-8.mol
- MSDS File:
- SDS
| Boiling point | 285.0±23.0 °C(Predicted) |
|---|---|
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 150 mg/mL (723.97 mM) |
| pka | -1.80±0.20(Predicted) |
| FDA UNII | KE4E342X6S |
3-methyl toxoflavin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CHM0292770 | 1,3,6-TRIMETHYL-PYRIMIDO[5,4-E]-1,2,4-TRIAZINE-5,7(1H,6H)-DIONE 95.00% | 32502-62-8 | 5MG | $501.86 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573135 | 3-methyl toxoflavin >98% | 32502-62-8 | 100mg | $838.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573135 | 3-methyl toxoflavin >98% | 32502-62-8 | 250mg | $1283.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573135 | 3-methyl toxoflavin >98% | 32502-62-8 | 1g | $2395.3 | 2021-12-16 | Buy |
| CSNpharm | CSN24071 | 35G8 | 32502-62-8 | 10mg | $221 | 2021-12-16 | Buy |
3-methyl toxoflavin Chemical Properties,Uses,Production
Definition
ChEBI: 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione is a pyrimidotriazine.
Biological Activity
3-Methyltoxoflavin is a potent inhibitor of protein disulfide isomerase (PDI) with IC50 of 170 nM.
in vitro
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC 50 of 170 nM. 3-Methyltoxoflavin is toxic in a panel of human glioblastoma cell lines. From the screen, 3-Methyltoxoflavin emerges as the most cytotoxic inhibitor of PDI. Bromouridine labeling and sequencing (Bru-seq) of nascent RNA reveals that 3-Methyltoxoflavin induces Nrf2 antioxidant response, ER stress response, and autophagy . Specifically, 3-Methyltoxoflavin upregulates heme oxygenase 1 and SLC7A11 transcription and protein expression and represses PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death does not proceed via apoptosis or necrosis, but by a mixture of autophagy and ferroptosis.
target
IC50: 170 nM (PDI).
3-methyl toxoflavin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Hekang Biotechnology Co., Ltd. | 18939837085 | youchemicals@gmail.com | China | 1823 | 55 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |