ALX 5407 Hydrochloride
- CAS No.
- 200006-08-2
- Chemical Name:
- ALX 5407 Hydrochloride
- Synonyms
- ALX 5407 HYDROCHLORIDE;(+/-)-NFPS HYDROCHLORIDE;(+/-)-NFPS HYDROCHLORIDE;N-[3-(4'-FLUOROPHENYL)-3-(4'-PHENYLPHENOXY)PROPYL]SARCOSINE HYDROCHLORIDE;(±)-NFPS hydrochloride, N-[3-(4μ-Fluorophenyl)-3-(4μ-phenylphenoxy)propyl]sarcosine hydrochloride
- CBNumber:
- CB6363477
- Molecular Formula:
- C24H25ClFNO3
- Molecular Weight:
- 429.91
- MDL Number:
- MFCD05664722
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H410 |
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 22-24/25-61-60 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
ALX 5407 Hydrochloride price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0897 | ALX 5407 hydrochloride ≥98% (HPLC) | 200006-08-2 | 5mg | $132 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0897 | ALX 5407 hydrochloride ≥98% (HPLC) | 200006-08-2 | 25mg | $417 | 2024-03-01 | Buy |
| Tocris | 1757 | ALX 5407 hydrochloride ≥98%(HPLC) | 200006-08-2 | 10 | $212 | 2021-12-16 | Buy |
| TRC | A575815 | ALX 5407 hydrochloride | 200006-08-2 | 1mg | $195 | 2021-12-16 | Buy |
| Usbiological | 285122 | NFPS hydrochloride | 200006-08-2 | 5mg | $420 | 2021-12-16 | Buy |
ALX 5407 Hydrochloride Chemical Properties,Uses,Production
Uses
ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.
Uses
ALX 5407 Hydrochloride can be used in the preparation of amino acid derivatives as pharmaceuticals for treatment of neurological and neuropsychiatric disorders.
Biochem/physiol Actions
ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).
storage
Desiccate at +4°C
References
[1]. atkinson bn, bell sc, de vivo m, et al. alx 5407: a potent, selective inhibitor of the hglyt1 glycine transporter. mol pharmacol, 2001, 60(6):1414-20.
ALX 5407 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |