Z-VDVAD-FMK
- CAS No.
- 210344-92-6
- Chemical Name:
- Z-VDVAD-FMK
- Synonyms
- Z-VDVAD-FMK;CASPASE-2 INHIBITOR I;Z-VD(OME)VAD(OME)-FMK;Z-VDVAD-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FMK;Z-VD(OME)VAD(OME)-FLUOROMETHYLKETONE;Z-VAL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE;BENZYLOXYCARBONYL-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
- CBNumber:
- CB6364843
- Molecular Formula:
- C32H46FN5O11
- Molecular Weight:
- 695.73
- MDL Number:
- MFCD03452881
- MOL File:
- Mol file
- MSDS File:
- SDS
Z-VDVAD-FMK price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 218744 | Caspase-2 Inhibitor I The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications. | 250μG | $201 | 2024-03-01 | Buy | |
| Sigma-Aldrich | C1605 | Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone powder, ≥95% (TLC) | 210344-92-6 | 1mg | $625 | 2024-03-01 | Buy |
| Sigma-Aldrich | 218744 | Caspase-2 Inhibitor I The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications. | 1MG | $561 | 2024-03-01 | Buy | |
| Chem-Impex | 32785 | Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone | 210344-92-6 | 1MG | $402.5 | 2021-12-16 | Buy |
| ApexBio Technology | A1922 | Z-VDVAD-FMK | 210344-92-6 | 10mg | $500 | 2021-12-16 | Buy |
Z-VDVAD-FMK Chemical Properties,Uses,Production
Biological Activity
Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
Biochem/physiol Actions
A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.
References
1. j. d. robertson, m. enoksson et al. caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. the journal of biological chemistry. 277, :29803–29809, 2002 2. t. meguro, b. chen et al. caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells, stroke. 2001; 32:561-566. 3. talanian, r. v., quinlan, c., trautz, s., hackett, m. c., mankovich, j. a., banach, d., ghayur, t., brady, k. d., and wong, w. w. (1997). substrate specificity of caspase family proteases. j. biol. chem. 272, 9677–9682. 4. gamen et al (2000) doxorubicin treatment activates a z-vad-sensitive caspase, which causes dym loss, caspase-9 activity, and apoptosis in jurkat cells. exp.cell res. 258 223.
Z-VDVAD-FMK Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-021-64543801 13764082696 | 2355241799@qq.com | China | 42982 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Alabiotech Inc. | 001-619-354-5251 | sales@alabiotech-e.com | United States | 972 | 60 |
| Alpha Biopharmaceuticals Co., Ltd | 0411-39042497 | sales@alphabiopharm.com | China | 1951 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |