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Z-DEVD-FMK

Z-DEVD-FMK structure

CAS No.: 210344-95-9

Chemical Name:: Z-DEVD-FMK

Synonyms: S7312;CS-1505;CTK8E8674;abs812077;Z-DEVD-FMK;AG-B-56189;CASPASE-3, INHIBITOR;CASPASE-3 INHIBITOR2;Z-DEVD-FMK USP/EP/BP;CASPASE-3 INHIBITOR II

CBNumber:: CB6453635

Molecular Formula:: C30H41FN4O12

Molecular Weight:: 668.66

MDL Number:: MFCD23380217

MOL File:: Mol file

MSDS File:: SDS

Last updated:2023-05-18 11:31:04

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Z-DEVD-FMK Properties

Boiling point	914.2±65.0 °C(Predicted)
Density	1.260±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO/DMF: ≥20 mM
pka	10.26±0.46(Predicted)
form	White to slightly brown solid

SAFETY

Risk and Safety Statements

WGK Germany	3

Z-DEVD-FMK price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	264155	Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.	210344-95-9	250μG	$144	2024-03-01	Buy
Sigma-Aldrich	264155	Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem	210344-95-9	1mg	$417	2024-03-01	Buy
Cayman Chemical	14414	Z-DEVD-FMK ≥95%	210344-95-9	500μg	$111	2024-03-01	Buy
Cayman Chemical	14414	Z-DEVD-FMK ≥95%	210344-95-9	1mg	$210	2024-03-01	Buy
Cayman Chemical	14414	Z-DEVD-FMK ≥95%	210344-95-9	5mg	$820	2024-03-01	Buy

Product number	Packaging	Price	Buy
264155	250μG	$144	Buy
264155	1mg	$417	Buy
14414	500μg	$111	Buy
14414	1mg	$210	Buy
14414	5mg	$820	Buy

Z-DEVD-FMK Chemical Properties,Uses,Production

Uses

Z-DEVD-FMK is an irrversible caspase-3 inhibitor used as an anaesthetic agent. In addition, it is proposed to increase the longevity of platelet storage.

Definition

ChEBI: Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an apoptosis inhibitor, an EC 3.4.22.56 (caspase-3) inhibitor and a neuroprotective agent.

General Description

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 μg/75 μl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.

Biological Activity

Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo .

Biochem/physiol Actions

Cell permeable: yes

target

Caspase-3

References

1. garcia-calvo m, peterson ep, leiting b, ruel r, nicholson dw, thornberry na (1998) inhibition of human caspases by peptidebased and macromolecular inhibitors. j biol chem 273:32608–32613 2. thornberry na, rano ta, peterson ep, rasper dm, timkey t, garcia-calvo m, houtzager vm, nordstrom pa, roy s, vaillancourt jp, chapman kt, nicholson dw (1997) a combinatorial approach defines specificities of members of the caspase family and granzyme b. functional relationships established for key mediators of apoptosis. j biol chem 272:17907–17911 3. yakovlev ag, knoblach sm, fan l, fox gb, goodnight r, faden ai (1997) activation of cpp32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. j neurosci 17:7415–7424 4. clark rs, kochanek pm, watkins sc, chen m, dixon ce, seidberg na, melick j, loeffert je, nathaniel pd, jin kl, graham sh (2000) caspase-3 mediated neuronal death after traumatic brain injury in rats. j neurochem 74:740–753 5. s. m. knoblach, d. a. alroy et al, caspase inhibitor z-devd-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury, journal of cerebral blood flow & metabolism 24:1119–1132.

Z-DEVD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

Z-DEVD-FMK Suppliers

Global( 145)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28149	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
Dideu Industries Group Limited	58
Nextpeptide Inc	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Zhejiang Hangyu API Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

210344-95-9(Z-DEVD-FMK)Related Search:

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Z-ASP-OME

1of3

Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-CH2F Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FMK Z-ASP(OME)-GLU(OME)-VAL-DL-ASP(OME)-FLUOROMETHYLKETONE Z-DEVD-FLUOROMETHYLKETONE Z-DEVD-FMK Z-D(OME)E(OME)VD(OME) FLUOROMETHYLKETONE Z-D(OME)E(OME)VD(OME)-FMK BENZYLOXYCARBONYL-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE CASPASE3/CPP32 INHIBITOR W-3 CASPASE-3, INHIBITOR CASPASE-3 INHIBITOR2 CASPASE-3 INHIBITOR (FLUOROMETHYLKETONE) CASPASE-3 INHIBITOR II L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester N-[(Phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide 1,2-dimethyl ester Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem AG-B-56189 CASPASE-3 INHIBITOR II; 210344-95-9; CASPASE-3 INHIBITOR; CTK8E8674; AG-B-56189; S7312;CASPASE-3 INHIBITOR;210344-95-9 CTK8E8674 S7312 CS-1505 Caspase-2 Inhibitor Z-VDVAD-FMK Z-DEVD-FMK USP/EP/BP abs812077 Z-DEVD-FMK, Caspase-3 inhibitor CBZ-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OM) 210344-95-9 210334-95-9 C30H41N4O12F Inhibitors Apoptosis peptides API Caspases/Apoptosis peptide Caspase/Related Products Pepetides