Cefazedone sodium salt
- CAS No.
- 63521-15-3
- Chemical Name:
- Cefazedone sodium salt
- Synonyms
- Nsc304118;Refosporin sodium salt;Cefazedone, sodium salt;Cefazedone sodium salt USP/EP/BP;Sodium (6R,7R)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;sodium (6R-trans)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;(6R,7R)-7-[[2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, monosodium salt, (6R-trans)-
- CBNumber:
- CB6878809
- Molecular Formula:
- C18H14Cl2N5NaO5S3
- Molecular Weight:
- 570.42503
- MDL Number:
- MFCD01682029
- MOL File:
- 63521-15-3.mol
- MSDS File:
- SDS
| FDA UNII | 658X66LF6Y |
|---|
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice, rats, rabbits, dogs (mg/kg): 6800, 4225, 3200, 3000 i.v. (von Eberstein) |
|---|
Cefazedone sodium salt Chemical Properties,Uses,Production
Originator
Cefazedone Sodium,Arocor Holdings Inc.
Manufacturing Process
A solution of 1 eq. of the tert-butyl ester of 7-aminocephalosporanic acid and
1 eq. of dicyclohexylcarbodiimide in 100 ml of methylene chloride/DMF (1:1)
is cooled to 0°C. The mixture is combined with 1 eq. of 3,5-dichloro-4-
pyridone-1-acetic acid; after 5 min the ice bath is removed and the mixture
agitated for another 30 min at 25°C. The thus-formed urea is filtered off and
the filtrate filtered over silica gel (eluent: ethyl acetate/1% methanol). The
solvent is concentrated by evaporation, and the thus-obtained tert-butyl ester
of 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid
is crystallized from ether.
1 eq. of the tert-butyl ester is dissolved in 30 ml of trifluoroacetic acid. After
30 minutes, the solution is evaporated and the thus-produced 7-(3,5-dichloro-
1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid crystallized from
ether.
1 eq. of the obtained 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)
cephalosporanic acid is dissolved in 60 ml of saturated aqueous sodium
bicarbonate solution at a pH of below 7 and combined with 1 eq. of 5-methyl-
1,3,4-thiadiazole-2-thiol in 20 ml of acetone. The reaction solution is agitated
for 2 hours at 80°C and at a pH of 6.3 under a nitrogen atmosphere. The
acetone is thereupon removed, the solution is washed with ether and acidified
to pH 2. The thus-obtained 3-(1-methyltetrazolyl-5-mercaptomethyl)-7-(3,5-
dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)-3-cephem-4-carboxylic acid is
filtered off and dried. IR spectrum confirmed the structure of cefazedone.
In practice it is usually used as sodium salt.
Therapeutic Function
Antibiotic
Cefazedone sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
Cefazedone sodium salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Hebei Runbin Biotechnology Co. LTD | 13180553332 | 2179877681@qq.com | CHINA | 996 | 58 |
| Hebei Henghe Import and Export Trading Co. LTD | +8618032935937 18032916000 | demi@hbtycoon.com | CHINA | 449 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28149 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9821 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
View Lastest Price from Cefazedone sodium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-01 | Cefazedone sodium salt USP/EP/BP
63521-15-3
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-12-11 | Cefazedone sodium
63521-15-3
|
US $260.00 / KG | 10KG | 99% | 10 | Hebei Henghe Import and Export Trading Co. LTD | |
 |
2020-08-26 | Cefazedone sodium salt
63521-15-3
|
US $235.00 / KG | 1KG | 99%min | 8000 Kilogram/Kilograms per Month | Hebei Runbin Biotechnology Co. LTD |
-
- Cefazedone sodium salt USP/EP/BP
63521-15-3
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Cefazedone sodium
63521-15-3
- US $260.00 / KG
- 99%
- Hebei Henghe Import and Export Trading Co. LTD
-
- Cefazedone sodium salt
63521-15-3
- US $235.00 / KG
- 99%min
- Hebei Runbin Biotechnology Co. LTD