S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate)
![S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) Structure](CAS/GIF/55560-96-8.gif)
- CAS No.
- 55560-96-8
- Chemical Name:
- S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate)
- Synonyms
- JO-1016;Tixocortolpivalate;TIXOCORTOL17PIVALATE;TIXOCORTOL-21PIVALATE;Cortisone Acetate Impurity 2;Tixocortol pivalate Solution, 100μg/mL;S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate);21-[(2,2-Dimethyl-1-oxopropyl)thio]-11β,17-dihydroxypregn-4-ene-3,20-dione;Pregn-4-ene-3,20-dione, 21-[(2,2-dimethyl-1-oxopropyl)thio]-11,17-dihydroxy-, (11β)-
- CBNumber:
- CB6908236
- Molecular Formula:
- C26H38O5S
- Molecular Weight:
- 462.64
- MDL Number:
- MFCD00866017
- MOL File:
- 55560-96-8.mol
- MSDS File:
- SDS
| Melting point | 195-200° |
|---|---|
| alpha | D20 +145° (c = 1 in dioxane) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Pale Yellow |
| FDA UNII | 6K28E35M3B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H413-H317 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T447500 | Tixocortol21-Pivalate | 55560-96-8 | 10mg | $175 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0015687 | TIXOCORTOL PIVALATE 95.00% | 55560-96-8 | 5MG | $504.65 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0015687 | TIXOCORTOL PIVALATE 95.00% | 55560-96-8 | 100MG | $2400 | 2021-12-16 | Buy |
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Originator
Pivalone,Jouveinal,France,1978
Uses
Free thiol in chemoaffinity labeling.
Uses
Tixocortol 21-Pivalate is an anti-inflammatory agent. Tixocortol 21-Pivalate is used in fluorescent chemoaffinity labeling.
Uses
Anti-inflammatory. Used in fluorescent chemoaffinity labeling.
Definition
ChEBI: The pivalate thioester of tixocortol.
Manufacturing Process
In a reactor of 50 liters, sodium S-thiopivalate is prepared from 100 g of S_x0002_thiopivalic acid (0.844 mol), 214 cc of solution of sodium methylate, 3.95 M
(0.844 mol) in 25 liters of anhydrous acetone.
There are then added 285 g (0.603 mol) of dihydroxy-11β,17α-iodo-21-dioxo-
3,20-pregnene-4 and the mixture is brought up to the acetone reflux for two
hours. The solvent is eliminated by distillation under vacuum until there is
obtained a syrupy residue which is poured into 10 liters of iced water. The
insoluble part is filtered and dried under vacuum.
The crude product is purified by recrystallization from ethanol; weight: 250 g;
yield: 89.5%.
Therapeutic Function
Antiinflammatory
Contact allergens
Tixocortol 21-pivalate is a 21-ester of tixocortol, widely used in topical treatments. It can induce severe allergic contact dermatitis. This corticosteroid is a marker of the allergenic A group that includes molecules without major substitution on the D cycle (no C 16 methylation, no C 17 side chain). A short-chain C 21 ester is possible. Molecules are cloprednol, cortisone, fludrocortisone, fluorometholone, hydrocortisone, methylprednisolone, methylprednisone, prednisolone, prednisone, tixocor- tol, and their C 21 esters (acetate, caproate or hexanoate, phosphate, pivalate or trimethylacetate, succinate or hemisuccinate, m-sulfobenzoate).
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17993 | 56 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4515 | 55 |
| Chengdu HuaNa Chemicals Co., Ltd. | 028-86612776; 13699069380 | 515238037@qq.com | China | 964 | 55 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55936 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |