9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI)
- CAS No.
- 634924-89-3
- Chemical Name:
- 9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI)
- Synonyms
- ANR 94;ANR-94 >=98% (HPLC);8-Ethoxy-9-ethyl-9H-purin-6-amine;9H-Purin-6-amine, 8-ethoxy-9-ethyl-;9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI)
- CBNumber:
- CB71294320
- Molecular Formula:
- C9H13N5O
- Molecular Weight:
- 207.23
- MDL Number:
- MFCD18086909
- MOL File:
- 634924-89-3.mol
- MSDS File:
- SDS
9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI) price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 3937 | ANR94 ≥99%(HPLC) | 634924-89-3 | 50 | $744 | 2021-12-16 | Buy |
| Tocris | 3937 | ANR94 ≥99%(HPLC) | 634924-89-3 | 10 | $189 | 2021-12-16 | Buy |
| TRC | A637248 | ANR94 | 634924-89-3 | 2.5mg | $250 | 2021-12-16 | Buy |
| Usbiological | 254640 | ANR 94 | 634924-89-3 | 10mg | $466 | 2021-12-16 | Buy |
| ApexBio Technology | B7540 | ANR94 | 634924-89-3 | 10mg | $322 | 2021-12-16 | Buy |
9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI) Chemical Properties,Uses,Production
Uses
ANR 94 is an adenosine A2A receptor antagonist, which may have a potential therapeutic role in treating Parkinson’s disease.
Biological Activity
8-ethoxy-9-ethyladenine (anr 94) had been characterized in vitro as an adenosine receptor antagonist. its chemical structure had been shown [1]. anr 94 has shown high selectivity and affinity for the human adenosine a2a receptor subtype and high antiparkinsonian activity in unilaterally 6-hydroxydopamine (6-ohda)-lesioned rats [2]. the ki value of anr 94 to the adenosine a2a receptor is 46 nm [1].adenosine is deeply involved in the control of motor behaviour and substantial evidences [1].in chinese hamster ovary (cho) cells stably transfected with human recombinant adenosine receptors, anr 94 was more selective than anr 82 at the adenosine a2a receptor, with a ki value of 46 nm [1]. treatment with anr 94 (0.5 mg/kg i.p. for 7 days) significantly prevented 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced degeneration of th-positive cells (p < 0.0005) [2].in rats, at a dose of 5 mg/kg i.p., anr 94 did not modify spontaneous motility, whereas at higher doses (10 or 15 mg/kg), it induced hypermotility. anr 94 at a dose of 1 mg/kg had a low efficacy on catalepsy, whereas 5 mg/kg was fully effective. in deeply cataleptic rats, anr 94 at a dose of 5 mg/kg i.p. during the 90-min testing period significantly reversed the catalepsy induced by 0.2 mg/kg of haloperidol. from 30-60 min, the effect of anr 94 was maximal. the anticataleptic effect of anr 94 had a long duration of over 150 min. in 6-ohda-lesioned rats, anr 94 significantly increased the number of contralateral rotations induced by l-dopa (3 mg/kg); this effect lasted up to 120-130 min [2].
storage
Store at RT
References
[1]. annalisa pinna, rosaria volpini, gloria cristalli, et al. new adenosine a2a receptor antagonists: actions on parkinson’s disease models. european journal of pharmacology, 2005, 512:157-164.
[2]. annalisa pinna, elisabetta tronci, nicoletta schintu, et al. a new ethyladenine antagonist of adenosine a2a receptors: behavioral and biochemical characterization as an antiparkinsonian drug. neuropharmacology, 2010, 58: 613-623.
9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
9H-Purin-6-amine,8-ethoxy-9-ethyl-(9CI) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 15502154572 | yuben012@sina.com | China | 502 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3574 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3688 | 58 |