Semagacestat
- CAS No.
- 425386-60-3
- Chemical Name:
- Semagacestat
- Synonyms
- LY450139;CS-1679;LY-4501);semagacestat;Unii-3yn0602W4w;Semagacestat/LY-450139;LY450139(Semagacestat);LY450139; LY-450139; LY 450139;Semagacestat LY450139 LY-450139;N-benzyl-4-MethylcyclohexanaMine
- CBNumber:
- CB71511579
- Molecular Formula:
- C19H27N3O4
- Molecular Weight:
- 361.44
- MDL Number:
- MFCD09970409
- MOL File:
- 425386-60-3.mol
- MSDS File:
- SDS
| Melting point | 208-212 °C |
|---|---|
| Boiling point | 681.9±55.0 °C(Predicted) |
| Density | 1.22 |
| Flash point | 366.2℃ |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 12.97±0.20(Predicted) |
| color | White |
| FDA UNII | 3YN0602W4W |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 29337900 |
Semagacestat price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16713 | Semagacestat ≥98% | 425386-60-3 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16713 | Semagacestat ≥98% | 425386-60-3 | 5mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 16713 | Semagacestat ≥98% | 425386-60-3 | 10mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 16713 | Semagacestat | 425386-60-3 | 25mg | $353 | 2024-03-01 | Buy |
| Tocris | 6559 | LY450139 ≥98%(HPLC) | 425386-60-3 | 25 | $322 | 2021-12-16 | Buy |
Semagacestat Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (Aβ), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer''s disease (AD).
Definition
ChEBI: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide is a peptide.
Biological Activity
semagacestat (also known as ly450139), [(2s)-2-hydroxy-n-((2s)-1-((1s)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[d]azepin-1ylamino)-1-oxopropan-2-yl)-3-methylbutanamide] is an azepine class γ-secretase, which is currently being investigated as a potential disease-modifying agent for the treatment of alzheimer’s disease (ad). it reduces the rate of formation of amyloid-β (aβ), a major component of the neuritic plaque in the brains of ad patients, in human subjects and animal models including mice, beagle dogs and guinea pigs. according to previous studies, semagacestat slows the accumulation of aβ in the brains of transgenic mice overexpressing mutant human amyloid precursor protein v717f (pdapp mice) and exhibits a dose-dependent decrease of plasma in ad patients.ping yi, chad hadden, palaniappan kulanthaivel, nathan calvert, william annes, thomas brown, robert j. barbuch, archana chaudhary, mosun a. ayan-oshodi, and barbara j. ring. disposition and metabolism of semagacestat, a γ-secretase inhibitor, in humans. drug metabolism and disposition 2010; 38(4): 554-565
target
Aβ42
storage
Store at -20°C
Semagacestat Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12823 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52861 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hebei Duling International Trade Co. LTD | +8617333973358 | sales01@hbduling.cn | China | 15620 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from Semagacestat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | Semagacestat
425386-60-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
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- Semagacestat
425386-60-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd