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(R)-MG132

(R)-MG132 structure

CAS No.: 1211877-36-9

Chemical Name:: (R)-MG132

Synonyms: D-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-;NSC60585;NSC 60585;MG-132(R);(R)-MG132;NSC-60585;MG-132(S,R,S);Z-Leu-D-leu-leu-al;(S,R,S)-(-)-MG-132;Cbz-L-leu-D-leu-L-leu-H

CBNumber:: CB72589829

Molecular Formula:: C26H41N3O5

Molecular Weight:: 475.62

MDL Number:: MFCD28580122

MOL File:: 1211877-36-9.mol

MSDS File:: SDS

Last updated:2023-07-12 17:26:46

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(R)-MG132 Properties

Boiling point	682.0±55.0 °C(Predicted)
Density	1.073±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
pka	11.14±0.46(Predicted)
form	powder

SAFETY

Risk and Safety Statements

WGK Germany	3

(R)-MG132 price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1135	MG-132(R) ≥95% (HPLC)	1211877-36-9	5mg	$482	2024-03-01	Buy
Sigma-Aldrich	M8699	(R)-MG132	1211877-36-9	1MG	$180	2023-06-20	Buy
Cayman Chemical	13697	(R)-MG132 ≥98%	1211877-36-9	1mg	$44	2024-03-01	Buy
Cayman Chemical	13697	(R)-MG132 ≥98%	1211877-36-9	5mg	$202	2024-03-01	Buy
Cayman Chemical	13697	(R)-MG132 ≥98%	1211877-36-9	10mg	$341	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1135	5mg	$482	Buy
M8699	1MG	$180	Buy
13697	1mg	$44	Buy
13697	5mg	$202	Buy
13697	10mg	$341	Buy

(R)-MG132 Chemical Properties,Uses,Production

Description

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression. (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC₅₀s = 0.22 versus 0.89 μM (ChTL); 34.4 versus 104.43 μM (TL); 2.95 versus 5.70 μM (PGPH), respectively).

Uses

(R)-MG-132 is a potent, reversible and selective tripeptide aldehyde proteasome inhibitor.

Uses

(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.

Definition

ChEBI: D-leucinamide, n-[(phenylmethoxy)carbonyl]-l-leucyl-n-[(1s)-1-formyl-3-methylbutyl]- is a peptide.

Biochem/physiol Actions

MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.

storage

Store at -20°C

(R)-MG132 Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-MG132 Suppliers

Global( 102)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9634	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nextpeptide Inc	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

1211877-36-9((R)-MG132)Related Search:

N-ACETYLLACTOSAMINE Dodecyl acrylate 5-METHYL-N,N-DIMETHYLTRYPTAMINE N-Methoxyphthalimide

(R)-MG132 Cbz-L-leu-D-leu-L-leu-H N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide MG-132(R) benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate MG-132(S,R,S) (S,R,S)-(-)-MG-132 Z-Leu-D-leu-leu-al N-benzyloxycarbonyl-L-leucyl-D-leucyl-L-leucinal NSC 60585 NSC60585 NSC-60585 D-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]- Benzyl ((S)-1-(((R)-1-amino-4-methyl-1-oxopentan-2-yl)((S)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate 1211877-36-9 peptides