ONO 7643 FuMarate
- CAS No.
- 339539-92-3
- Chemical Name:
- ONO 7643 FuMarate
- Synonyms
- RC1291 FuMarate;RC-1291 FuMarate;ONO7643 FuMarate;RC 1291 FuMarate;ONO-7643 FuMarate;ONO 7643 FuMarate;AnaMorelin (FuMarate);Anamorelin (RC-1291) Fumarate;Anamorelin fumarate (RC-1291 Fumarate;RC-1291 FUMARATE;ONO-7643 FUMARATE;RC1291 FUMARATE;ONO7643 FUMARATE;RC 1291 FUMARATE;ONO 7643 FUMARATE
- CBNumber:
- CB72666588
- Molecular Formula:
- C35H46N6O7
- Molecular Weight:
- 662.79
- MDL Number:
- MFCD23098789
- MOL File:
- 339539-92-3.mol
ONO 7643 FuMarate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb611813 | Anamorelin fumarate | 339539-92-3 | 10mg | $229.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611813 | Anamorelin fumarate | 339539-92-3 | 50mg | $402.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611813 | Anamorelin fumarate | 339539-92-3 | 100mg | $414.8 | 2021-12-16 | Buy |
| Crysdot | CD31002186 | AnamorelinFumarate 98+% | 339539-92-3 | 50mg | $1050 | 2021-12-16 | Buy |
| Crysdot | CD31002186 | AnamorelinFumarate 98+% | 339539-92-3 | 100mg | $1470 | 2021-12-16 | Buy |
ONO 7643 FuMarate Chemical Properties,Uses,Production
Description
Anamorelin Fumarate is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
in vitro
In Vitro:In the FLIPR assay, Anamorelin (ANAM) shows significant agonist activity on the ghrelin receptor, with EC50 value of 0.74 nM. No significant antagonist activity is observed with Anamorelin at concentrations of up to 1,000 nM. In the binding experiments, Anamorelin binds to the ghrelin receptor with a binding affinity constant (Ki) of 0.70 nM. In the competition assay with radiolabeled ibutamoren (35S-MK-677; another ghrelin receptor agonist) Anamorelin (ANAM) is also found to bind with high affinity to the ghrelin receptor (IC50=0.69 nM). In rat pituitary cells incubated with Anamorelin, there is a dose-dependent stimulatory effect on GH release and the potency (EC50) is 1.5 nM. Anamorelin is screened for activity against a set of over 100 receptors, ion channels, transporters, and enzymes. Anamorelin demonstrates binding to the tachykinin neurokinin 2 (NK2) site (IC50=0.021 μM); however, a subsequent NK2 functional assay demonstrates no functional activity[1].
in vivo
In Vivo:In rats, Anamorelin (ANAM) at an oral dose of 3, 10, or 30 mg/kg once daily significantly increases both food intake and body weight from Day 2 to Day 7 of treatment compared with the vehicle control. The cumulative change in food intake and weight gain increases dose-dependently, and these changes are significant at all dose levels (P<0.05) compared to the control. Administration of Anamorelin at a single oral dose of 3, 10, or 30 mg/kg induces a dose-dependent increase in plasma GH levels and GH AUC0-6h in rats[1].
References
References:[1]. Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37.
ONO 7643 FuMarate Preparation Products And Raw materials
Raw materials
Preparation Products
ONO 7643 FuMarate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| Chengdu Saiousi Pharmaceutical Co., Ltd | 028-64971018 18108168130 | China | 1781 | 55 | |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Career Henan Chemica Co | 58 |
| MedChemexpress LLC | 58 |
| AdooQ BioScience, LLC | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 55 |
| Chengdu Saiousi Pharmaceutical Co., Ltd | 55 |
| Musechem | 60 |
| DC Chemicals | 58 |
| Absin Bioscience Inc. | 58 |