ETC-1002
- CAS No.
- 738606-46-7
- Chemical Name:
- ETC-1002
- Synonyms
- Bempedoic Acid;Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-;CS-1544;ETC-1002;ESP 55016;Bempedoic;Bempedoate;Bempdic acid;Bempedoic Acid, API;ETC-1002 (ESP 55016)
- CBNumber:
- CB73034632
- Molecular Formula:
- C19H36O5
- Molecular Weight:
- 344.49
- MDL Number:
- MFCD18800820
- MOL File:
- 738606-46-7.mol
- MSDS File:
- SDS
| Melting point | 87 - 92°C |
|---|---|
| Boiling point | 506.5±35.0 °C(Predicted) |
| Density | 1.045±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 4.55±0.45(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24) |
| InChIKey | HYHMLYSLQUKXKP-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O |
| FDA UNII | 1EJ6Z6Q368 |
| ATC code | C10AX15 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
ETC-1002 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26409 | ETC-1002 | 738606-46-7 | 25mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 26409 | ETC-1002 | 738606-46-7 | 50mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 26409 | ETC-1002 | 738606-46-7 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 26409 | ETC-1002 | 738606-46-7 | 10mg | $50 | 2024-03-01 | Buy |
| TRC | B119700 | BempedoicAcid | 738606-46-7 | 250mg | $605 | 2021-12-16 | Buy |
ETC-1002 Chemical Properties,Uses,Production
Description
ETC-1002 is a prodrug form of ETC-1002-CoA. ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.
Description
Etc-1002 is a small molecule that can be used orally to lower LDL-C and is an activator of LIVER AMPK. ETC-1002 has an effective inhibitory effect on liver ATP-Citrate lyase.
Uses
ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).
Definition
ChEBI: Bempedoic acid is an alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'. It has a role as an antilipemic drug, an EC 2.3.3.8 (ATP citrate synthase) inhibitor and a prodrug.
ETC-1002 Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
ETC-1002 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Anhuida Chemical Co., Ltd | +8615903659408 | admin@ahdchem.com | China | 298 | 58 |
| Shanghai Famo Biotech Co Ltd | +8618550473860 | mayan@famobiotech.com | China | 509 | 58 |
| Beijing Hope Pharmaceutical Co., Ltd. | +86-010-67886402 +8613611125266 | market@hopelife.cn | China | 71 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21688 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 723 | 55 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7154 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
Related articles
- How is Bempedoic Acid Synthesised?
- Bempedoic Acid (ETC-1002) is synthesised using ethyl isobutyrate as raw material by chemical reaction.
- Dec 27，2023
View Lastest Price from ETC-1002 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-28 | Bempedoic Acid
738606-46-7
|
US $0.00 / KG | 25KG | 98% | Inquiry | PNP Biotech Co. Ltd | |
 |
2023-02-03 | Bempedoic acid
738606-46-7
|
US $0.00 / G | 1G | 98%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2022-10-11 | Bempedoic acid (ETC-1002)
738606-46-7
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Bempedoic Acid
738606-46-7
- US $0.00 / KG
- 98%
- PNP Biotech Co. Ltd
-
- Bempedoic acid
738606-46-7
- US $0.00 / G
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Bempedoic acid (ETC-1002)
738606-46-7
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.