CGP 20712 dihydrochloride
- CAS No.
- 1216905-73-5
- Chemical Name:
- CGP 20712 dihydrochloride
- Synonyms
- 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol dihydrochloride
- CBNumber:
- CB73037183
- Molecular Formula:
- C23H26ClF3N4O5
- Molecular Weight:
- 530.93
- MDL Number:
- MFCD06798358
- MOL File:
- 1216905-73-5.mol
CGP 20712 dihydrochloride price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | C583548 | CGP20712Dihydrochloride | 1216905-73-5 | 25mg | $330 | 2021-12-16 | Buy |
ApexBio Technology | B6552 | CGP20712dihydrochloride | 1216905-73-5 | 50mg | $1362 | 2021-12-16 | Buy |
ApexBio Technology | B6552 | CGP20712dihydrochloride | 1216905-73-5 | 10mg | $329 | 2021-12-16 | Buy |
CGP 20712 dihydrochloride Chemical Properties,Uses,Production
Uses
CGP 20712 Dihydrochloride is a highly potent and selective β1-AR antagonist.
Biological Activity
cgp 20712 dihydrochloride is a potent and selective antagonist of β1-adrenoceptor with ic50 value of 0.7 nm [1].β1-adrenoceptor is a g-protein coupled receptor and mediates uncoupling protein-1 (ucp1) gene expression induced by norepinephrine (ne) [2].cgp 20712 dihydrochloride is a potent and selective β1-adrenoceptor antagonist. in neocortical membranes, cgp 20712 a exhibited affinity for β1-adrenoceptor and β2-adrenoceptor with ic50 values of 0.7 and 6700 nm, respectively [1]. in brown adipocytes, cgp-20712a significantly inhibited ucp1 gene expression induced by ne. however, cgp-20712a had no effect on lipolysis. these results suggested that β1-adrenoceptor mediated ucp1 gene expression [2]. in ventricular membranes from rats, cgp 20712a (300 nm) completely occupied its high-affinity binding sites. in ventricular myocytes isolated from rats, cgp 20712a (10, 100, 1000 nm) didn’t cause the activation of adenylate cyclase mediated by β2-adrenoceptors, which suggested that β2-adrenoceptors were not present on rat ventricular myocytes [3]. in adult rat cardiac myocytes, cgp 20712a inhibited β1-ar-stimulated apoptosis, which was mediated by a camp-dependent mechanism [4].
storage
Desiccate at +4°C
References
[1]. dooley dj, bittiger h, reymann nc. cgp 20712 a: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. eur j pharmacol, 1986, 130(1-2): 137-139.
[2]. chaudhry a, granneman jg. differential regulation of functional responses by beta-adrenergic receptor subtypes in brown adipocytes. am j physiol, 1999, 277(1 pt 2): r147-153.
[3]. kitagawa y, adachi-akahane s, nagao t. determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. br j pharmacol. 1995, 116(1): 1635-1643.
[4]. communal c, singh k, sawyer db, et al. opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive g protein. circulation, 1999, 100(22): 2210-2212.
CGP 20712 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
CGP 20712 dihydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4191 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
Aladdin Scientific | 58 |
BOC Sciences | 65 |
EMMX Biotechnology LLC | 60 |
Energy Chemical | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 58 |
ApexBio Technology | 58 |