yk11
- CAS No.
- 1370003-76-1
- Chemical Name:
- yk11
- Synonyms
- yk1;YK-ll;YK-11-OA;Hot sell;YK11;YK 11;sarms YK11;yk11/mk677;YK-11 powder;YK11-1 gram(44);YK11 White Powder
- CBNumber:
- CB73055372
- Molecular Formula:
- C25H34O6
- Molecular Weight:
- 430.53
- MDL Number:
- MFCD30343804
- MOL File:
- 1370003-76-1.mol
| Melting point | 134-137°C |
|---|---|
| Boiling point | 564.4±50.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Pale Yellow |
| InChIKey | KCQHQCDHFVGNMK-PQUNLUOYSA-N |
| FDA UNII | Z9748J6B0R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H334-H317-H341-H361-H370-H413 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501 | |||||||||
| NFPA 704 |
|
yk11 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9003137 | YK-11 | 1370003-76-1 | 10mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 9003137 | YK-11 | 1370003-76-1 | 100mg | $263 | 2024-03-01 | Buy |
| Cayman Chemical | 9003137 | YK-11 | 1370003-76-1 | 50mg | $156 | 2024-03-01 | Buy |
| TRC | Y120025 | YK-11(Mixtureofdiasteromers) | 1370003-76-1 | 50mg | $175 | 2021-12-16 | Buy |
| DC Chemicals | DC10809 | YK-11 >98% | 1370003-76-1 | 100mg | $450 | 2021-12-16 | Buy |
yk11 Chemical Properties,Uses,Production
Description
YK11 was first studied by Japanese researcher Yuichiro Kanno in 2011. It was found to be a partial agonist of the androgen receptor (AR), genetically selective, leading researchers to believe the compound was a SARM. YK11 is an experimental drug candidate and an unapproved substance for use in humans.
Uses
YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM).It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.
Mechanism of action
YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.1 It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.
References
[1] Yuichiro Kanno, et al. Exp Cell Res. Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells DOI:10.1016/j.yexcr.2022.113333
[2] Su Jin Lee, et al. Biochem Biophys Res Commun. Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis DOI:10.1016/j.bbrc.2021.01.030
[3] Tomofumi Yatsu, et al. Biol Pharm Bull. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells DOI:10.1248/bpb.b17-00748
[4] Mario Thevis, et al. Mol Cell Endocrinol. Detection of SARMs in doping control analysis DOI:10.1016/j.mce.2017.01.040
[5] Yuichiro Kanno, et al. Biol Pharm Bull. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression DOI:10.1248/BPB.B13-00231
yk11 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 | sales@cellwh.com | China | 376 | 58 |
| Zhuzhou New Peptides Tech Co.,Ltd. | +8618073326374 | sales@goodpeptides.com | China | 140 | 58 |
| qingdao future trading Co., Ltd | +86-13335044410 +86-13335044410 | cui56813@163.com | China | 110 | 58 |
| Wuhan Ruichi Technology Co., Ltd | +8613545065237 | admin@whrchem.com | China | 164 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 | Ethan@dornechem.com | China | 293 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 305 | 58 |
Related articles
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- YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM). SARMs are very similar to steroids because they i....
- Mar 21，2022
View Lastest Price from yk11 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-19 | yk11
1370003-76-1
|
US $1.00-1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD | |
 |
2024-05-17 | YK-11
1370003-76-1
|
US $90.00 / kg | 1kg | 99.9% | 1000 | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-05-17 | YK11
1370003-76-1
|
US $9.90-17339.00 / g | 1g | 99% | 25kg | Wuhan Cell Pharmaceutical Co., Ltd |