Leucettine L41
- CAS No.
- 1112978-84-3
- Chemical Name:
- Leucettine L41
- Synonyms
- Leucettine L41;Leucettine L41,Leucettine L-41;4H-Imidazol-4-one, 5-(1,3-benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-, (5Z)-
- CBNumber:
- CB73152956
- Molecular Formula:
- C17H13N3O3
- Molecular Weight:
- 307.3
- MDL Number:
- MOL File:
- 1112978-84-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| NFPA 704 |
|
Leucettine L41 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29225 | Leucettine L41 | 1112978-84-3 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 29225 | Leucettine L41 | 1112978-84-3 | 10mg | $448 | 2024-03-01 | Buy |
| Cayman Chemical | 29225 | Leucettine L41 | 1112978-84-3 | 5mg | $239 | 2024-03-01 | Buy |
| Usbiological | 207259 | Leucettine L41 | 1112978-84-3 | 1mg | $295 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-MR-C0023-M025 | LeucettineL41 ≥98%(NMR) | 1112978-84-3 | 25mg | $880 | 2021-12-16 | Buy |
Leucettine L41 Chemical Properties,Uses,Production
Description
Leucettine L41 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 μM, respectively).1 It also inhibits GSK3α/β and Pim1 with IC50 values of 0.41 and 4.1 μM, respectively. It inhibits phosphorylation of the serine/arginine (SR) protein 9G8 by DYRK2, DYRK3, CLK1, CLK2, and CLK4 and inhibits TNF-α-induced SRp75 and SRp55 phosphorylation in human microvascular endothelial cells when used at concentrations ranging from 0.1 to 10 μM. Leucettine L41 modulates alternative pre-RNA splicing of a synthetic CLK1 minigene in a reporter model. It prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by amyloid-β 25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity.2 Leucettine L41 (0.4, 1.2, and 4 μg, i.c.v.) also prevents memory deficits induced by amyloid-β 25-35 in the same model.
References
1. Debdab, M., Carreaux, F., Renault, S., et al. Leucettines, a class of potent inhibitors of cdc2-
2. Naert, G., Ferré, V., Meunier, J., et al. Leucettine L41, a DYRK1A-
Leucettine L41 Preparation Products And Raw materials
Raw materials
Preparation Products
Leucettine L41 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 997 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 2881924050@qq.com | China | 9892 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |