4-METHOXY-1H-INDAZOL-3-AMINE
- CAS No.
- 886362-07-8
- Chemical Name:
- 4-METHOXY-1H-INDAZOL-3-AMINE
- Synonyms
- 4-methoxy-1H-indazol-4-amine;4-METHOXY-1H-INDAZOL-3-AMINE;1H-Indazol-3-aMine, 4-Methoxy-;4-Methoxy-1H-indazol-3-ylamine;4-(Methyloxy)-1H-indazol-3-amine;3-Amino-4-methoxy-1H-indazole 95%
- CBNumber:
- CB8135645
- Molecular Formula:
- C8H9N3O
- Molecular Weight:
- 163.18
- MDL Number:
- MFCD08276946
- MOL File:
- 886362-07-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
4-METHOXY-1H-INDAZOL-3-AMINE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 755192 | 3-Amino-4-methoxy-1H-indazole 96% | 886362-07-8 | 1g | $66.5 | 2023-01-07 | Buy |
| Alfa Aesar | H33750 | 3-Amino-4-methoxy-1H-indazole, 97% | 886362-07-8 | 1g | $166 | 2021-12-16 | Buy |
| Alfa Aesar | H33750 | 3-Amino-4-methoxy-1H-indazole, 97% | 886362-07-8 | 5g | $555 | 2021-12-16 | Buy |
| Alfa Aesar | H33750 | 3-Amino-4-methoxy-1H-indazole, 97% | 886362-07-8 | 250mg | $61 | 2021-12-16 | Buy |
| Matrix Scientific | 046012 | 4-Methoxy-1H-indazol-3-amine >95% | 886362-07-8 | 1g | $63 | 2021-12-16 | Buy |
4-METHOXY-1H-INDAZOL-3-AMINE Chemical Properties,Uses,Production
Uses
4-Methoxy-1H-indazol-3-amine is used as a reactant in the preparation and structure-activity relationship of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists.
Synthesis
A mixture of 2-fluoro-6-(methyloxy)benzonitrile (8a) (10 g, 66 mmol) and hydrazine hydrate (9.63 mL, 198 mmol) in n-butanol (100 mL) was heated to reflux under nitrogen for 18 h. The reaction mixture was allowed to cool, water (300 mL) was added and the organic phase was removed. The solid in the aqueous phase was collected by filtration and dried in vacuo at 40 ??C to give a white solid (0.6 g). The butanol phase was evaporated in vacuo and the residue and the aqueous mother liquors were combined and extracted using ethyl acetate (2 ?á 200 mL). The combined ethyl acetate extractions were dried (MgSO4) and evaporated in vacuo. The residue was dissolved in DCM and applied to a 100 g silica cartridge. This was eluted with cyclohexane (500 mL), cyclohexane ethyl acetate (1:1, 500 mL) and ethyl acetate (500 mL). The required fractions were combined and evaporated in vacuo to give 9a (9.92 g, 92%) as an off-white solid. MS ES + ve m/z 164 (M + H)+. 1H NMR |? (DMSO-d6) 11.35 (1H, s), 7.10 (1H, t, J = 8 Hz), 6.76 (1H, d, J = 8 Hz), 6.29 (1H, d, J = 8 Hz), 4.95 (2H, br s), 3.85 (3H, s).
4-METHOXY-1H-INDAZOL-3-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 | market03@meryer.com | China | 40240 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30132 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35906 | 56 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 | sales@shydchem.com.cn | China | 982 | 56 |
View Lastest Price from 4-METHOXY-1H-INDAZOL-3-AMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-01 | 4-METHOXY-1H-INDAZOL-3-AMINE
886362-07-8
|
US $1.00 / KG | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
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- 4-METHOXY-1H-INDAZOL-3-AMINE
886362-07-8
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co