LEPTIN, HUMAN
- CAS No.
- 177404-21-6
- Chemical Name:
- LEPTIN, HUMAN
- Synonyms
- ARHB;ARH6;RHOB;rHuL;LEPTIN;MST081;HUMAN OB;OB HUMAN;HUMAN LEPTIN;LEPTIN, HUMAN
- CBNumber:
- CB8229593
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01094205
- MOL File:
- Mol file
| storage temp. | −20°C |
|---|---|
| form | lyophilized powder |
| NCI Dictionary of Cancer Terms | leptin |
| FDA UNII | Q09SXY6BFI |
LEPTIN, HUMAN price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L4146 | Leptin human >97% (SDS-PAGE) | 177404-21-6 | 1mg | $281 | 2024-03-01 | Buy |
| Sigma-Aldrich | 429700 | Leptin, Human, Recombinant, | 177404-21-6 | 1mg | $468 | 2024-03-01 | Buy |
| Usbiological | L1669-01N | Leptin | 177404-21-6 | 500ug | $498 | 2021-12-16 | Buy |
| Usbiological | L1671-25K | Leptin | 177404-21-6 | 1mg | $531 | 2021-12-16 | Buy |
| Usbiological | L1671-25M | Leptin | 177404-21-6 | 1mg | $531 | 2021-12-16 | Buy |
LEPTIN, HUMAN Chemical Properties,Uses,Production
Structure
Leptin is produced as a 167-aa residue preprohormone, including an N-terminal 21-aa signal peptide, and is released as a 146-aa peptide after enzymatic cleavage.
Properties
Human leptin: Mr 16,000, pI 5.8. Leptin is soluble in water.
Uses
Leptin analogs are used for the treatment of lipodystrophy in clinical settings.
Gene, mRNA, and precursor
The human leptin gene, LEP, location 7q31.3, consists of three exons. Human leptin mRNA has a 3.5kb length that encodes a signal peptide of 21 aa residues and a mature protein of 146 aa residues.
Regulation of synthesis and release
The synthesis and release of leptin are regulated by environmental factors. In humans and rodents, obesity stimulates leptin synthesis and increases the plasma concentrations. Exercise decreases the plasma leptin concentrations in the rat. Exposure to low temperature suppresses leptin gene expression in WAT and reduces the plasma leptin concentrations in rodents. While fasting attenuates leptin gene expression, feeding restores the levels of gene expression.
Description
Leptin is an adipocyte hormone secreted from white adipose tissues that regulates energy expenditure and food intake by acting on receptors located in the hypothalamus.
LEPTIN, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
LEPTIN, HUMAN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-021-64543801 13764082696 | 2355241799@qq.com | China | 42982 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 18521735133 18521732826; | market@aladdin-e.com | China | 25014 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18016477331 | synchempharma@aliyun.com | China | 6456 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
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