2,2-Difluoro-1,3-benzodioxole
- CAS No.
- 1583-59-1
- Chemical Name:
- 2,2-Difluoro-1,3-benzodioxole
- Synonyms
- 2,2-Difluoro-1,3-ben;uoro-1,3-benzodioxoL;LABOTEST-BB LT01148491;2,2-DIFLUOROBENZODIOXOLE;2,2-Difluoro-1,3-benzodixole;2,2-DIFLUORO-1,3-BENZODIOXOLE;difluoromethylenedioxybenzene;2,2-DIFLUORO-BENZO[1,3]DIOXOLE;2,2-difluoro-1,3-benozodioxole;1,3-Benzodioxole, 2,2-difluoro-
- CBNumber:
- CB8295369
- Molecular Formula:
- C7H4F2O2
- Molecular Weight:
- 158.1
- MDL Number:
- MFCD00236217
- MOL File:
- 1583-59-1.mol
- MSDS File:
- SDS
| Boiling point | 129-130°C |
|---|---|
| Density | 1,308 g/cm3 |
| refractive index | 1.443 |
| Flash point | 129-130°C |
| storage temp. | 2-8°C |
| solubility | Chloroform, Methanol |
| form | Oil |
| color | Clear Colourless |
| BRN | 1307648 |
| InChIKey | DGCOGZQDAXUUBY-UHFFFAOYSA-N |
| LogP | 2.96 |
| CAS DataBase Reference | 1583-59-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-43 | |||||||||
| Safety Statements | 26-36/37/39-36/37 | |||||||||
| RIDADR | UN1993 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2932990090 | |||||||||
| NFPA 704 |
|
2,2-Difluoro-1,3-benzodioxole price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 740756 | 2,2-Difluoro-1,3-benzodioxole 97% | 1583-59-1 | 5g | $23.5 | 2024-03-01 | Buy |
| TCI Chemical | D4051 | 2,2-Difluoro-1,3-benzodioxole >98.0%(GC) | 1583-59-1 | 5g | $42 | 2024-03-01 | Buy |
| TCI Chemical | D4051 | 2,2-Difluoro-1,3-benzodioxole >98.0%(GC) | 1583-59-1 | 25g | $126 | 2024-03-01 | Buy |
| Alfa Aesar | B20540 | 2,2-Difluoro-1,3-benzodioxole, 97% | 1583-59-1 | 5g | $65.65 | 2024-03-01 | Buy |
| Alfa Aesar | B20540 | 2,2-Difluoro-1,3-benzodioxole, 97% | 1583-59-1 | 25g | $200.65 | 2024-03-01 | Buy |
2,2-Difluoro-1,3-benzodioxole Chemical Properties,Uses,Production
Uses
2,2-Difluoro-1,3-benzodioxole is an intermediate compound which is used especially for the preparation of products for agricultural chemistry and for the synthesis of pharmaceutical products.
2,2-difluoro-1,3-benzodioxole is a useful difluoromethylated building block for the synthesis of various benzodioxole-containing pharmaceutical active compounds.
2-,3-,and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds.
Selective aliphatic fluorination by halogen exchange in mild conditions.
Preparation
2,2-Difluoro-1,3-benzodioxole is prepared by reaction of 2,2-dichloro-1,3-benzodioxole with potassium fluoride in the presence of an effective quantity of a catalyst selected from potassium hydrogen fluoride, sodium hydrogen fluoride, cesium hydrogen fluoride, rubidium hydrogen fluoride, and quaternary ammonium hydrogen fluoride.
https://patents.google.com/patent/US5432290A/en
References
[1] E.Castagnetti, et al, Eur. J. Org. Chem., 2001, 2001(4), pp 691-695.
[2] L.Saint-Jalmes, J. F. Chem., 2006, 127(1), pp 85-90.
Chemical Properties
Colorless to pale yellow liquid
Uses
2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.
2,2-Difluoro-1,3-benzodioxole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5963 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18229 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15957 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com | jocelynpan@zjarts.com | CHINA | 993 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from 2,2-Difluoro-1,3-benzodioxole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | Ethynyltrimethylsilane
1583-59-1
|
US $10.00 / kg | 1kg | 99.6% | 100000 | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-12-27 | 2,2-Difluoro-1,3-benzodioxole
1583-59-1
|
US $80.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-07-25 | 2,2-Difluoro-1,3-Benzodioxole
1583-59-1
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD |
-
- Ethynyltrimethylsilane
1583-59-1
- US $10.00 / kg
- 99.6%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 2,2-Difluoro-1,3-benzodioxole
1583-59-1
- US $80.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,2-Difluoro-1,3-Benzodioxole
1583-59-1
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD