ceralifimod
- CAS No.
- 891859-12-4
- Chemical Name:
- ceralifimod
- Synonyms
- ONO-4641;ceralifimod;Ceralifimod (ONO-4641);Ceralifimod (Synonyms: ONO-4641);3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-
- CBNumber:
- CB83032842
- Molecular Formula:
- C27H33NO4
- Molecular Weight:
- 435.56
- MDL Number:
- MFCD28502037
- MOL File:
- 891859-12-4.mol
- MSDS File:
- SDS
| Boiling point | 595.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.172±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:5.0(Max Conc. mg/mL);11.48(Max Conc. mM) |
| form | A crystalline solid |
| pka | 2.71±0.20(Predicted) |
| FDA UNII | BZ2O8A84A4 |
ceralifimod price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24159 | Ceralifimod ≥95% | 891859-12-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24159 | Ceralifimod ≥95% | 891859-12-4 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 24159 | Ceralifimod ≥95% | 891859-12-4 | 10mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 24159 | Ceralifimod ≥95% | 891859-12-4 | 25mg | $305 | 2024-03-01 | Buy |
| Tocris | 6690 | Ceralifimod ≥95%(HPLC) | 891859-12-4 | 10 | $123 | 2021-12-16 | Buy |
ceralifimod Chemical Properties,Uses,Production
Description
Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively). It is selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively). Ceralifimod induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P1 or S1P5 (EC50s = 0.027 and 0.33 nM, respectively). In vivo, ceralifimod (0.03 and 0.1 mg/kg) reduces paw edema in a rat model of collagen induced arthritis (CIA). It also delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of experimental autoimmune encephalomyelitis (EAE) and prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE.
storage
Store at -20°C
ceralifimod Preparation Products And Raw materials
Raw materials
Preparation Products
ceralifimod Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
| Shanghai Medicil Biomedical Co., Ltd. | 021-50822001 | marketing@medicilon.com.cn | China | 1152 | 58 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |