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RO8994

RO8994 Structure
RO8994 structure
CAS No.
1309684-94-3
Chemical Name:
RO8994
Synonyms
RO8994;CS-2264;RO-8994;RO 8994;RO8994;RO-8994;RO 8994;(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-;(2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-;E2 conjugating enzyme,MDM-2/p53,Ubiquitin conjugating enzyme,Ubiquitin activating enzyme,E3 ligating enzyme,RO8994,inhibit,Inhibitor,RO 8994,RO-8994,E1/E2/E3 Enzyme,E1 activating enzyme,Ubiquitin ligase
CBNumber:
CB83041727
Molecular Formula:
C31H31Cl2FN4O4
Molecular Weight:
613.51
MDL Number:
MFCD29472243
MOL File:
1309684-94-3.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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RO8994 Properties

Boiling point 753.5±60.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM)
DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM)
form A crystalline solid
pka 12.00±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

RO8994 price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25674 RO8994 1309684-94-3 1mg $68 2024-03-01 Buy
Cayman Chemical 25674 RO8994 1309684-94-3 25mg $1169 2024-03-01 Buy
Cayman Chemical 25674 RO8994 1309684-94-3 5mg $286 2024-03-01 Buy
Cayman Chemical 25674 RO8994 1309684-94-3 10mg $535 2024-03-01 Buy
TRC R637390 RO8994 1309684-94-3 2.5mg $200 2021-12-16 Buy
Product number Packaging Price Buy
25674 1mg $68 Buy
25674 25mg $1169 Buy
25674 5mg $286 Buy
25674 10mg $535 Buy
R637390 2.5mg $200 Buy

RO8994 Chemical Properties,Uses,Production

Description

RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC50 = 5 nM). It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC50 value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively.

Uses

RO 8994 is a potent and selective spiroindolinone MDM2 inhibitor, and potential useful for cancer therapy.

RO8994 synthesis

1419186-19-8
1309684-94-3
Synthesis of RO8994 from Benzoic acid, 4-[(2-aminoacetyl)amino]-3-methoxy-, methyl ester, hydrochloride (1:1)

RO8994 Preparation Products And Raw materials

Raw materials

Benzoic acid, 4-[(2-aminoacetyl)amino]-3-methoxy-, methyl ester, hydrochloride (1:1) 6-Chlorooxindole

Preparation Products

RO8994 Suppliers

Global( 54)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32686 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42057 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Changzhou Chenhong Biotechnology Co., Ltd. 0519-85788828 13775037613 sales@chemrenpharm.com China 3553 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED
60
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Changzhou Chenhong Biotechnology Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
RO8994 (2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)- RO-8994;RO 8994 RO8994;RO-8994;RO 8994 CS-2264 E2 conjugating enzyme,MDM-2/p53,Ubiquitin conjugating enzyme,Ubiquitin activating enzyme,E3 ligating enzyme,RO8994,inhibit,Inhibitor,RO 8994,RO-8994,E1/E2/E3 Enzyme,E1 activating enzyme,Ubiquitin ligase (2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'- 1309684-94-3 C31H31Cl2FN4O4