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EFT-508

EFT-508 structure

CAS No.: 1849590-01-7

Chemical Name:: EFT-508

Synonyms: EFT-508;CS-2450;eFT508 -MNK;Tomivosertib;eFT-508 (eFT508);Tomivosertib eFT508;eFT508(Tomivosertib);EFT 508;EFT-508;TOMIVOSERTIB;6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione;6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione

CBNumber:: CB83133222

Molecular Formula:: C17H20N6O2

Molecular Weight:: 340.38

MDL Number:: MFCD30489732

MOL File:: 1849590-01-7.mol

Last updated:2023-05-18 11:31:22

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EFT-508 Properties

Melting point	>300°C
Boiling point	735.6±60.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	Refrigerator, under inert atmosphere
solubility	DMSO (Slightly, Heated), Methanol (Very Slightly)
pka	13.77±0.60(Predicted)
form	Solid
color	Pale Yellow
FDA UNII	U2H19X4WBV
NCI Drug Dictionary	tomivosertib

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933998090

EFT-508 price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21957	eFT508 ≥98%	1849590-01-7	1mg	$68	2024-03-01	Buy
Cayman Chemical	21957	eFT508 ≥98%	1849590-01-7	5mg	$302	2024-03-01	Buy
Cayman Chemical	21957	eFT508 ≥98%	1849590-01-7	10mg	$535	2024-03-01	Buy
Cayman Chemical	21957	eFT508 ≥98%	1849590-01-7	25mg	$1002	2024-03-01	Buy
TRC	A629153	6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione	1849590-01-7	5mg	$150	2021-12-16	Buy

Product number	Packaging	Price	Buy
21957	1mg	$68	Buy
21957	5mg	$302	Buy
21957	10mg	$535	Buy
21957	25mg	$1002	Buy
A629153	5mg	$150	Buy

EFT-508 Chemical Properties,Uses,Production

Description

eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC₅₀s = <10 nM). It inhibits phosphorylation of eukaryotic initiation factor 4E (eIF4E) with an IC₅₀ value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats.

Uses

6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione was used in the study of inhibitors of immune checkpoint modulators and related methods. eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor.

EFT-508 Preparation Products And Raw materials

Raw materials

Preparation Products

EFT-508 Suppliers

Global( 83)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
BOC Sciences	58
career henan chemical co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from EFT-508 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-09	EFT-508 1849590-01-7	US $9.80 / KG	1g	≥99%	100kg	Career Henan Chemical Co

EFT-508
1849590-01-7
US $9.80 / KG
≥99%
Career Henan Chemical Co

1849590-01-7(EFT-508)Related Search:

2,4,6-Triaminopyrimidine

EFT-508 6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione eFT508 -MNK 6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione Tomivosertib eFT508 CS-2450 EFT 508;EFT-508;TOMIVOSERTIB 6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione Spiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione, 6'-[(6-amino-4-pyrimidinyl)amino]-8'-methyl- eFT508(Tomivosertib) Tomivosertib eFT-508 (eFT508) 6'-((6-Aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione 6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2',5'-dihydro-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione 6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione 1849590-01-7 849590-01-7