Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>S63845

S63845

S63845 Structure
S63845 structure
CAS No.
1799633-27-4
Chemical Name:
S63845
Synonyms
S63845;CS-2485;CS-2477;S63845 TFA;S 63845;S-63845;Inhibitor,S63845,S-63845,S 63845,Bcl-2 Family,inhibit;(2R)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;(S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-, (αR)-
CBNumber:
CB83147768
Molecular Formula:
C39H37ClF4N6O6S
Molecular Weight:
829.26
MDL Number:
MFCD31382374
MOL File:
1799633-27-4.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

S63845 Properties

Boiling point 852.6±65.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light, stored under nitrogen
solubility insoluble in H2O; ≥20 mg/mL in MeOH; ≥41.45 mg/mL in DMSO
form A crystalline solid
pka 2.54±0.11(Predicted)
FDA UNII TVF3XUQ4PG

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2934999090

S63845 price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21131 S63845 ≥98% 1799633-27-4 500μg $86 2024-03-01 Buy
Cayman Chemical 21131 S63845 ≥98% 1799633-27-4 1mg $104 2024-03-01 Buy
Cayman Chemical 21131 S63845 ≥98% 1799633-27-4 5mg $212 2024-03-01 Buy
ApexBio Technology A8737 S63845 1799633-27-4 5mg $300 2021-12-16 Buy
ApexBio Technology A8737 S63845 1799633-27-4 25mg $1000 2021-12-16 Buy
Product number Packaging Price Buy
21131 500μg $86 Buy
21131 1mg $104 Buy
21131 5mg $212 Buy
A8737 5mg $300 Buy
A8737 25mg $1000 Buy

S63845 Chemical Properties,Uses,Production

Description

S63845 is an inhibitor of myeloid cell leukemia 1 (Mcl-1; Ki = 0.19 nM), a pro-survival protein that is overexpressed in many cancers. It induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = <0.1-282 nM) via mitochondrial apoptosis. S63845 acts synergistically with trametinib , lapatinib , PLX4032 , and erlotinib to reduce proliferation of SK-MEL-2, BT474, A2058, and PC9 cells, respectively. S63845 (6.25-25 mg/kg) reduces tumor volume in an MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner.

Uses

S-63845 is used in killing senescent cells and treating senescence-associated diseases or disorders using a combination of a BCL inhibitor and an MCL-1 inhibitor.Potent and selective MCL1 inhibitor

S63845 Preparation Products And Raw materials

Raw materials

Preparation Products

S63845 Suppliers

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49391 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
CR Corporation Lomited 		fred.wen@crcorporation.cn CHINA 12069 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Jiangsu shring Biopharma Co., Ltd. 		+8613372282299 sales@shringchem.com China 3545 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
CONIER CHEM AND PHARMA LIMITED 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Chemia Biotechnology（Shanghai） Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
CR Corporation Lomited 		58
InvivoChem 		58
Jiangsu shring Biopharma Co., Ltd. 		58

View Lastest Price from S63845 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
S63845; pictures 2019-09-02 S63845;
1799633-27-4
 US $1.00-1.00 / KG 1KG 98% 1lg; 2kg; 5kg; 10kg; 100kg Career Henan Chemical Co
  • S63845; pictures
  • S63845;
    1799633-27-4
  • US $1.00-1.00 / KG
  • 98%
  • Career Henan Chemical Co

S63845 Spectrum

S63845(1799633-27-4)1HNMR

1799633-27-4(S63845)Related Search:

S811 S5011
S63845 (R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid (2R)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-, (αR)- S 63845;S-63845 CS-2477 CS-2485 S63845 TFA (S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid Inhibitor,S63845,S-63845,S 63845,Bcl-2 Family,inhibit 1799633-27-4 C39H37ClF4N6O6S API