ChemicalBook >> CAS DataBase List >>MAK-683
MAK-683
- CAS No.
- 1951408-58-4
- Chemical Name:
- MAK-683
- Synonyms
- MAK-683;CPD 1111;EED inhibitor-1;MAK 683;MAK-683;MAK683;MAK683,EED inhibitor-1;inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683;N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID;N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine;1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-
- CBNumber:
- CB83334085
- Molecular Formula:
- C20H17FN6O
- Molecular Weight:
- 376.39
- MDL Number:
- MFCD31630846
- MOL File:
- 1951408-58-4.mol
Last updated:2023-05-21 10:59:17
| Density | 1.47±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO: 15 mg/ml |
| form | A solid |
| pka | 2.70±0.12(Predicted) |
| FDA UNII | 4K446Z8N51 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MAK-683 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29316 | MAK-683 | 1951408-58-4 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 29316 | MAK-683 | 1951408-58-4 | 10mg | $593 | 2024-03-01 | Buy |
| Cayman Chemical | 29316 | MAK-683 | 1951408-58-4 | 5mg | $336 | 2024-03-01 | Buy |
| TRC | M198120 | MAK-683 | 1951408-58-4 | 1mg | $85 | 2021-12-16 | Buy |
| ChemScene | CS-8054 | MAK683 98.05% | 1951408-58-4 | 5mg | $130 | 2021-12-16 | Buy |
MAK-683 Chemical Properties,Uses,Production
Description
MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM.
Uses
MAK-683 is a useful intermediate for the preparation of triazolopyrimidine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2. EED inhibitor-1.
MAK-683 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 61)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8348 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
CPD 1111
MAK-683
EED inhibitor-1
MAK 683;MAK-683;MAK683
N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID
1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-
inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683
MAK683,EED inhibitor-1
1951408-58-4