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4-Hydroxy-D-(-)-2-phenylglycine

4-Hydroxy-D-(-)-2-phenylglycine structure

CAS No.: 22818-40-2

Chemical Name:: 4-Hydroxy-D-(-)-2-phenylglycine

Synonyms: (R)-2-AMino-2-(4-hydroxyphenyl)acetic acid;H-D-PHG(4-OH)-OH;D-4-HYDROXYPHENYLGLYCINE;4-HYDROXY-D-PHENYLGLYCINE;(R)-(-)-2-Phenylglycine amide;AMoxicillin Related CoMpound I;(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid;B8372699;H-D-HPG-OH;D-4-OH-Phg-OH

CBNumber:: CB8372699

Molecular Formula:: C8H9NO3

Molecular Weight:: 167.16

MDL Number:: MFCD00004262

MOL File:: 22818-40-2.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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4-Hydroxy-D-(-)-2-phenylglycine Properties

Melting point	240 °C (dec.)(lit.)
alpha	-156 º (c=1, 1 N HCl)
Boiling point	295.73°C (rough estimate)
Density	1.396
vapor pressure	0Pa at 25℃
refractive index	-158 ° (C=1, 1mol/L HCl)
storage temp.	2-8°C
solubility	5g/l
form	Liquid
pka	2.15±0.10(Predicted)
color	Clear colorless to yellow
optical activity	[α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility	5 g/L (20 ºC)
BRN	2210998
LogP	-2.25
CAS DataBase Reference	22818-40-2(CAS DataBase Reference)
FDA UNII	PCM9OIX717
EPA Substance Registry System	Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-24/25

WGK Germany

TSCA

Yes

HS Code

29225000

NFPA 704

	0
2		0

4-Hydroxy-D-(-)-2-phenylglycine price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2196	Amoxicillin Related Compound I	22818-40-2	50MG	$485	2024-03-01	Buy
Sigma-Aldrich	215333	4-Hydroxy-D-phenylglycine ≥98%	22818-40-2	25g	$50.1	2023-06-20	Buy
Sigma-Aldrich	1031591	Amoxicillin Related Compound I United States Pharmacopeia (USP) Reference Standard	22818-40-2	25mg	$1310	2022-05-15	Buy
TCI Chemical	H0758	4-Hydroxy-D-(-)-2-phenylglycine >99.0%(HPLC)(T)	22818-40-2	25g	$40	2024-03-01	Buy
TCI Chemical	H0758	4-Hydroxy-D-(-)-2-phenylglycine >99.0%(HPLC)(T)	22818-40-2	100g	$77	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR2196	50MG	$485	Buy
215333	25g	$50.1	Buy
1031591	25mg	$1310	Buy
H0758	25g	$40	Buy
H0758	100g	$77	Buy

4-Hydroxy-D-(-)-2-phenylglycine Chemical Properties,Uses,Production

Description

d-(p-Hydroxyphenyl)glycine (d-HPG) is widely used in large amounts as an important intermediate for the synthesis of amoxicillin and several other semisynthetic β-lactam antibiotics.

Chemical Properties

off-white powder

Uses

4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Uses

4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Definition

ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.

Flammability and Explosibility

Non flammable

reaction suitability

reaction type: solution phase peptide synthesis

Purification Methods

Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]

4-Hydroxy-D-(-)-2-phenylglycine Preparation Products And Raw materials

Raw materials

DL-P-Hydroxyphenylglycine Glyoxal Phenol DL-Tartaric acid D(-)-Tartaric acid

p-Anisaldehyde Glyoxylic acid

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Preparation Products

D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM (2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-(4-hydroxyphenyl)acetic acid (R)-3-BROMO-4-HYDROXYPHENYLGLYCINE Fmoc-D-4-Hydroxyphenylglycine (R)-AMINO-4-HYDROXY-CYCLOHEXANEACETIC ACID

4-Hydroxy-D-(-)-2-phenylglycine Suppliers

Global( 545)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12809	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18137	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	861	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19805	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Apeloa production Co.,Limited	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 4-Hydroxy-D-(-)-2-phenylglycine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-23	4-Hydroxy-D-(-)-2-phenylglycine 22818-40-2	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-15	4-Hydroxy-D-(-)-2-phenylglycine 22818-40-2	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-03-21	4-Hydroxy-D-(-)-2-phenylglycine 22818-40-2	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd

4-Hydroxy-D-(-)-2-phenylglycine
22818-40-2
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Hydroxy-D-(-)-2-phenylglycine
22818-40-2
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Hydroxy-D-(-)-2-phenylglycine
22818-40-2
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

4-Hydroxy-D-(-)-2-phenylglycine Spectrum

4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)MS 4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)¹HNMR 4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)IR1 4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)IR2 4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2)Raman

22818-40-2(4-Hydroxy-D-(-)-2-phenylglycine)Related Search:

4-Hydroxybenzoic acid 4-Aminophenylacetic acid 6-Aminocaproic acid D-2-Phenylglycine Glycine

CHLOROPHOSPHONAZO III Methylparaben Betaine 4-Hydroxyphenylacetic acid Anilinoacetic acid

α-Lipoic Acid D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM,D-(-)-ALPHA-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM L-Phenylglycine 4-Hydroxybenzaldehyde D-4-Hydroxyphenylglycine methyl ester

D(+)-Trehalose dihydrate D(+)-Malic acid (S)-Amlodipine

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(R)-4-HYDROXYPHENYLGLYCINE (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE D-(-)-2-(4-HYDROXYPHENYL)GLYCINE D(-)-2-(P-HYDROXYPHENYL)GLYCINE D-(-)-A-4-HYDROXYPHENYLGLYCINE D-4-HYDROXYPHENYLGLICYNE D-(-)-4-HYDROXYPHENYLGLYCINE D-ALPHA-PARA-HYDROXYPHENYLGLYCINE (D)-(-)-ALFA-4-HYDROXYPHENYL GLYCINE D-(-)-P-HYDROXYPHENYLGLYCINE D-P-HYDROXYPHENYLGLYCINE D(-)PARA-HYDROXY-PHENYLGLYCINE HYDROXY PHENYL GLYCINE H-D-HPG-OH H-D-PHG(4-HYDROXY)-OH (theta)-benzeneaceticaci .alpha.-amino-4-hydroxy-,(R)-Benzeneaceticacid a-Amino-p-hydroxyphenylaceticacid Benzeneaceticacid,alpha.-amino-4-hydroxy-,(R)- Benzeneaceticacid,-amino-4-hydroxy-,(R)- L-(-)-4-Hydroxy-α-aminophenylacetic acid D(-)-P-Hydroxyphenylglycine, 98+% (2R)-2-(4-Hydroxyphenyl)glycine (R)-2-(p-Hydroxyphenyl)glycine p-Hydroxy-D-phenylglycine α-(4-Hydroxyphenyl)-D-glycine (2R)-2-Amino-2-(4-hydroxyphenyl)ethanoic acid, (R)-Amino(4-hydroxyphenyl)acetic acid Amoxicillin Related Compound I (15 mg) ((R)-2-Amino-2-(4-hydroxyphenyl)acetic acid) D(-)-4-Hydroxyphenylglycine, 98+% 100GR D(-)-4-Hydroxyphenylglycine, 98+% 25GR D(-)-4-Hydroxyphenylglycine ,99% D(-)-alpha-para-Hydroxyphenylglycine base (R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic Acid 4-Hydroxy-D-phenylglycine Benzeneacetic acid, a-aMino-4-hydroxy-, (aR)- 4-Hydroxy-D-(-)-2-phenylglycine AMoxicillin EP IMpurity I (-)-4-Hydroxy-D-phenylglycine, 98+% D-(-)p-hydroxyphenylgcine Dane salt 4-Hydroxy-D-(-)-2-phenylglycine, 99.0%(LC&T D(-)-4-Hydroxyphenylglycine 4-Hydroxy-D-phenylglycine Cefprozil impurity A Cefadroxyl impurity A D-N-(4-hydroxyphenyl)glycine Parahydroxy phenylglycine base D-a-(-)-parahydroxyphenylgycine (2R)-2-amino-(4-Hydroxyphenyl)acetic acid D-4-HYDROXYPHENYLGLYCINE, 98+% d-p-hydroxyglycine (2R)-amino(4-hydroxyphenyl)acetic acid 2-(4-Hydroxy-phenyl)glycin D-Form D-(-)-p-Hydroxy Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (r)-(-)-à-amino-(4-hydroxyphenyl)acetic acid D(-)-P-HYDROXYPHENYLGLYCINE BASE (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE 99+% (R)-(4-HYDROXYPHENYL)GLYCINE (4-HYDROXY-D-PHENYLGLYCINE) D-(-)-4-HYDROXYPHENYLGLYCINE, NA OR K SALT PARA-HYDROXYPHENYLGLYCINE