Tocofersolan
- CAS No.
- 9002-96-4
- Chemical Name:
- Tocofersolan
- Synonyms
- tpgs;VITAMIN E TPGS;Vitamin E polyethylene glycol succinate;d-alpha-tocopheryl polyethylene glycol succinate;Tocophersolan;D-α-Tocopherol polyethylene glycol succinate;tocopherosolan;D-a-Tocopherol Polyethylene Glycol Succinate;d-alpha-tocopherylpoly(ethyleneglycol)1000succinate;D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)
- CBNumber:
- CB8396198
- Molecular Formula:
- (C2H4O)nC33H54O5
- Molecular Weight:
- 0
- MDL Number:
- MFCD00146616
- MOL File:
- 9002-96-4.mol
| Melting point | 34-38°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble1g/10 mL, clear to faintly turbid, colorless to faintly yellow |
| form | Solid |
| color | White to Pale Yellow Waxy |
| InChI | InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3 |
| InChIKey | WFWQYXBTWIHIIW-UHFFFAOYSA-N |
| SMILES | C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO |
| LogP | 9.745 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | O03S90U1F2 |
| NCI Drug Dictionary | tocophersolan |
| ATC code | A11HA08 |
Tocofersolan price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 57668 | D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate | 9002-96-4 | 5g | $88.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 57668 | D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate | 9002-96-4 | 25g | $310 | 2024-03-01 | Buy |
| TCI Chemical | T3118 | α-Tocopherol Polyethylene Glycol Succinate | 9002-96-4 | 5G | $70 | 2024-03-01 | Buy |
| TCI Chemical | T3118 | α-Tocopherol Polyethylene Glycol Succinate | 9002-96-4 | 25G | $240 | 2024-03-01 | Buy |
| Strem Chemicals | 08-2180 | DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) TPGS-750-M | 9002-96-4 | 10ml | $23 | 2021-12-16 | Buy |
Tocofersolan Chemical Properties,Uses,Production
Chemical Properties
Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.
Uses
tocophersolan is an anti-oxidant, this is a water-soluble form of vitamin e.
Uses
Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
Production Methods
Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.
Pharmaceutical Applications
Vitamin E polyethylene glycol succinate is an esterified vitamin E
(tocopherol) derivative primarily used as a solubilizer or emulsifying
agent because of its surfactant properties. Structurally, it is
amphipathic and hydrophilic, unlike the tocopherols, and therefore
it is a water-soluble derivative that can be used in pharmaceutical
formulations such as capsules, tablets, hot-melt extrusion,
microemulsions, topical products, and parenterals. One of
the most important applications is its use as a vehicle for lipid-based
drug delivery formulations. It can also be used as a source of
vitamin E.
Vitamin E polyethylene glycol succinate has been characterized
with respect to its mechanism of action and studied as a Pglycoprotein
inhibitor.
Biochem/physiol Actions
D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) also known as vitamin E TPGS, is a therapeutic agent for vitamin E deficiency in children, administered during chronic childhood cholestasis. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins. TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles.
Safety
Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.
storage
Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.
Incompatibilities
Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Tocofersolan Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | sales006@ingredients-lonier.com | China | 2596 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12467 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 16801 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
View Lastest Price from Tocofersolan manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Tocofersolan
9002-96-4
|
US $0.00-0.00 / KG | 1KG | 99% | 10000 Mt/Year | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2024-04-02 | Tocofersolan
9002-96-4
|
US $34.00-1.30 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-11-27 | Tocofersolan;TPGS
9002-96-4
|
US $1500.00 / kg | 1kg | 99% | 2 tons | Wuhan Senwayer Century Chemical Co.,Ltd |
-
- Tocofersolan
9002-96-4
- US $0.00-0.00 / KG
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Tocofersolan
9002-96-4
- US $34.00-1.30 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Tocofersolan;TPGS
9002-96-4
- US $1500.00 / kg
- 99%
- Wuhan Senwayer Century Chemical Co.,Ltd