ChemicalBook >> CAS DataBase List >>Rimegepant sulfate
Rimegepant sulfate
- CAS No.
- 1374024-48-2
- Chemical Name:
- Rimegepant sulfate
- Synonyms
- RIMEGEPANT SULFATE;Rimegepant sulfate hydrate;Rimegepant hemisulfate sesquihydrate;[(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl]4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate;(5S,6S,9R)-5-amino-6-(2,3difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b] pyridin-9-yl4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate sesquihydrate;(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate hemisulfate sesquihydrate;Rimegepant sulfate hydrate【Chemical name：1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester, sulfate, hydrate (2:1:3)】
- CBNumber:
- CB84748603
- Molecular Formula:
- C28H30F2N6O7S
- Molecular Weight:
- 632.64
- MDL Number:
- MOL File:
- 1374024-48-2.mol
Last updated:2023-12-22 11:24:27
| FDA UNII | 1383NM3Q0H |
|---|
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373-H361d |
| Precautionary statements | P260-P314-P501 |
Rimegepant sulfate Chemical Properties,Uses,Production
Description
Rimegepant sulfate is a small molecule, highly selective calcitonin gene-related peptide antagonist (CGRP) developed by Biohaven Pharmaceutical Holdings, Inc. and approved by the FDA for the acute treatment of migraine. rimegepant and ubrogepant are the only CGRP antagonists with oral bioavailability. Because of the absence of vasoconstrictive properties observed with oral CGRP antagonists, the use of rimegepant is safer and more reliable in patients with contraindications to standard therapy[1].
Side effects
Common side effects of Rimegepant sulfate are nausea, which may be severe enough to cause shortness of breath, difficulty breathing; swelling of the face, eyes, mouth, throat, tongue, or lips; rash, measles; and itching.
Synthesis
Rimegepant sulfate is prepared by the reaction of rimegepant and water.
Step: With sulfuric acid In ethanol at 20 - 70℃; Solvent; Temperature.
References
[1] J S. Rimegepant: First Approval.[J]. Drugs, 2020, 80 7: 741-746. DOI:10.1007/s40265-020-01301-3.
Rimegepant sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
Rimegepant sulfate Suppliers
Global( 67)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7154 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| SyncoZymes (Shanghai) Co., Ltd., | +86-021-68187180-811 +86-13681683526 | lchen@syncozymes.com | China | 188 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | sales006@ingredients-lonier.com | China | 2605 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 8472 | 58 |
| Protheragen-ING | +16313385890 | info@protheragen-ing.com | United States | 1091 | 58 |
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View Lastest Price from Rimegepant sulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-11-01 | Rimegepant Sulfate
1374024-48-2
|
US $0.00-0.00 / kg | 1kg | 99.0% | 20 tons | Hangzhou ICH Biofarm Co., Ltd |
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- Rimegepant Sulfate
1374024-48-2
- US $0.00-0.00 / kg
- 99.0%
- Hangzhou ICH Biofarm Co., Ltd
[(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl]4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate hemisulfate sesquihydrate
Rimegepant sulfate hydrate【Chemical name：1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester, sulfate, hydrate (2:1:3)】
RIMEGEPANT SULFATE
(5S,6S,9R)-5-amino-6-(2,3difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b] pyridin-9-yl4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate sesquihydrate
Rimegepant sulfate hydrate
Rimegepant hemisulfate sesquihydrate
1374024-48-2
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