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ChemicalBook >> CAS DataBase List >>4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Structure
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione structure
CAS No.
2093416-32-9
Chemical Name:
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Synonyms
Thalidomide-PEG2-C2-NH2;Thalidomide-NH-PEG2-C2-NH2;Thalidomide-4-NH-PEG2-C2-NH2;4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
CBNumber:
CB84849371
Molecular Formula:
C19H24N4O6
Molecular Weight:
404.42
MDL Number:
MFCD32263424
MOL File:
2093416-32-9.mol
Last updated:2023-02-23 14:24:01
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4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
DC Chemicals 027582 Thalidomide-PEG2-C2-NH2 2093416-32-9 002 $850 2021-12-16 Buy
A1 Biochem Labs A1-26739 4-((2-(2-(2-Aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 95% 2093416-32-9 1g $1200 2021-12-16 Buy
DC Chemicals DC50056 Thalidomide-PEG2-C2-NH2 2093416-32-9 1g $1700 2021-12-16 Buy
Product number Packaging Price Buy
027582 002 $850 Buy
A1-26739 1g $1200 Buy
DC50056 1g $1700 Buy

4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties,Uses,Production

Biological Activity

Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Suzhou Highfine Biotech Co., Ltd 0512-68311833 13962195826 wuhao@highfine.com China 498 75
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 6854 65
ChemShuttle, Inc. 0510-83588313-802 18800520310; sales@chemshuttle.com China 3062 62
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7892 56
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9754 58
Shanghai CR Corporation Limited 4006653949 fred.wen@crcorporation.cn China 10108 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1296 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Suzhou Highfine Biotech Co., Ltd 75
Daicel Chiral Technologies (China)CO.,LTD 65
ChemShuttle, Inc. 62
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Chaolan Chemical Technology Center 58
Shanghai CR Corporation Limited 58
Jilin Province Woda Biotechnology Co., Ltd. 58
DC Chemicals 58

2093416-32-9(4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione)Related Search:

Thalidomide-O-amido-C2-NH2 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione -alkylC5-amine Thalidomide-NH-C6-NH2 TFA 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
E3 ligase Ligand-Linker Conjugates 15 Thalidomide-O-amido-C2-NH2 Thalidomide-NH-PEG2-C2-NH2 hydrochloride Thalidomide-NH-PEG2-C2-NH2 (TFA)

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4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Thalidomide-NH-PEG2-C2-NH2 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Thalidomide-PEG2-C2-NH2 Thalidomide-4-NH-PEG2-C2-NH2 2093416-32-9