DOTMA
- CAS No.
- 104872-42-6
- Chemical Name:
- DOTMA
- Synonyms
- R-DOTMA-Cl;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt);N,N,N-Trimethyl-2,3-bis(octadec-9-en-1-yloxy)propan-1-aminium chloride;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)(DOTMA)
- CBNumber:
- CB86188272
- Molecular Formula:
- C42H84ClNO2
- Molecular Weight:
- 670.59
- MDL Number:
- MOL File:
- 104872-42-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
DOTMA Chemical Properties,Uses,Production
Description
DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome.
Uses
DOTMA is used for drug delivery and gene transfection. When used as a component of liposomes, it is used to encapsulate siRNAs, miRNAs and oligonucleotides, etc., to form carrier liposomes (LPX), which are used in anticancer vaccine research.DOTMA has shown good gene transfection effects both in vitro and in vivo. It can also be used as a development of new visualisers.
Biochem/physiol Actions
DOTMA is a cationic lipid, used as a non-viral vector for gene therapy. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome - cell membrane interaction.
DOTMA Preparation Products And Raw materials
Raw materials
Preparation Products
DOTMA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | changaiwei@sinopeg.com | China | 59 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7154 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Meike meditech (Foshan) Co.,Ltd | +86-0757-22239986 +86-18029359586 | sales@mkmeditech.com | China | 1134 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shochem(Shanghai)Co.,Ltd | +86-021-51783479 +86-13816874662 | info@shochem.com | China | 295 | 58 |
| BeiJing Hwrk Chemicals Limted | 0757-86329057 18501085097 | sales3.gd@hwrkchemical.com | China | 7639 | 55 |