cycloastragenol
- CAS No.
- 84605-18-5
- Chemical Name:
- cycloastragenol
- Synonyms
- Cyclogalegigenin;Cycloastrageno;(3beta,6alpha,16beta,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;Cyclogalegenin;Cyclogalagenin;cas 84605-18-5;cas 78574-94-4;Cyclogalgeginin;Cycloastragenol, >98%;cas 84605-18-5 78574-94-4
- CBNumber:
- CB91378734
- Molecular Formula:
- C30H50O5
- Molecular Weight:
- 490.71
- MDL Number:
- MFCD11618124
- MOL File:
- 84605-18-5.mol
- MSDS File:
- SDS
| Melting point | >220°C (dec.) |
|---|---|
| Boiling point | 617.2±55.0 °C(Predicted) |
| Density | 1.20 |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) |
| form | Solid |
| pka | 14.57±0.29(Predicted) |
| color | White |
| FDA UNII | X37D9F2L0V |
cycloastragenol price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11722 | Cycloastragenol ≥98% | 84605-18-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 11722 | Cycloastragenol ≥98% | 84605-18-5 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 11722 | Cycloastragenol ≥98% | 84605-18-5 | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 11722 | Cycloastragenol ≥98% | 84605-18-5 | 25mg | $381 | 2024-03-01 | Buy |
| TRC | C987810 | Cycloastragenol | 84605-18-5 | 1g | $210 | 2021-12-16 | Buy |
cycloastragenol Chemical Properties,Uses,Production
Description
Cycloastragenol (TA-65), a small-triterpenoid purified from the root of an Asian medicinal herb, has currently received particular attention for its potential to regulate transcription of telomerase. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.
Biological Activity
Cycloastragenol, the aglycone derivative of astragaloside A, can be found in various species of Astragalus and is reported to activate telomerase. It has been shown to slow telomere loss, increase replicative capacity, and improve immune function in CD8+ T lymphocytes from HIV-1-infected patients.
Laboratory Procedures
Cycloastragenol is supplied as a crystalline solid. A stock solution may be made by dissolving the cycloastragenol in the solvent of choice. Cycloastragenol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of cycloastragenol in these solvents is approximately 10, 3, and 25 mg/ml, respectively.
Cycloastragenol is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, cycloastragenol should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Cycloastragenol has a solubility of approximately 0.25 mg/ml in a 1:8 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Uses
Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.
Definition
ChEBI: A sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus.
cycloastragenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu King-tiger Pharm-chem. Tech. Co., Ltd. | 028-85317716 18202897410 | sales@king-tiger.com | China | 6 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 943 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 326 | 58 |
| Shandong Juchuang Chemical Co., LTD | +undefined15030412209 | admin@juchuangchem.com | China | 387 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
Related articles
- Cycloastragenol: pharmacokinetics, activities and side effects
- Cycloastragenol shows potential for diverse health applications but requires further study for safety.
- Nov 23，2023
- What is cycloastragenol?
- Cycloastragenol is isolated from Astragalus species.
- Aug 20，2021
- Pharmacological Effects of Cycloastragenol
- Cycloastragenol (CAG), an aglycone of astragaloside IV, is a triterpenoid saponin compound and a hydrolysis product of the mai....
- Oct 28，2019
View Lastest Price from cycloastragenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-11 | Cycloastragenol,98%
84605-18-5
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 3.5%-98% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
 |
2024-05-07 | cycloastragenol
84605-18-5
|
US $0.00-0.00 / kg | 1kg | 99% | 500000kh | Hebei Kingfiner Technology Development Co.Ltd | |
 |
2024-03-11 | cycloastragenol
84605-18-5
|
US $18.00-5.00 / kg | 500kg | 99.9 | 200tons | Shandong Juchuang Chemical Co., LTD |
-
- Cycloastragenol,98%
84605-18-5
- US $0.00-0.00 / kg
- 3.5%-98%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- cycloastragenol
84605-18-5
- US $0.00-0.00 / kg
- 99%
- Hebei Kingfiner Technology Development Co.Ltd
-
- cycloastragenol
84605-18-5
- US $18.00-5.00 / kg
- 99.9
- Shandong Juchuang Chemical Co., LTD
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